Immunophilins: Structures, Mechanisms and Ligands

• Published in: Current molecular pharmacology Vol. 9; no. 1; p. 37
• Main Authors: Harikishore, Amaravadhi, Yoon, Ho Sup
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2016
• Subjects: Drug Discovery - methods; Humans; Immunophilins - antagonists & inhibitors; Immunophilins - chemistry; Immunophilins - metabolism; Ligands; Malaria - drug therapy; Malaria - parasitology; Models, Molecular; Plasmodium - chemistry; Plasmodium - drug effects; Plasmodium - metabolism; Protein Conformation; Protozoan Proteins - antagonists & inhibitors; Protozoan Proteins - chemistry; Protozoan Proteins - metabolism

Immunophilins consist of a family of highly conserved proteins which possess binding abilities to immunosuppressive drugs. Cyclophilins (Cyps) and FK506-binding proteins (FKBP) are family proteins collectively referred as immunophilins. Most Cyps and FKBP family members catalyse peptidyl-prolyl cis/...