Comparative genomics of Crohn's disease-associated adherent-invasive Escherichia coli

• Published in: Gut Vol. 66; no. 8; pp. 1382 - 1389
• Main Authors: O'Brien, Claire L, Bringer, Marie-Agnès, Holt, Kathryn E, Gordon, David M, Dubois, Anaëlle L, Barnich, Nicolas, Darfeuille-Michaud, Arlette, Pavli, Paul
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2017; BMJ Publishing Group
• Subjects: Bacteria; Bacterial Adhesion; Bacteriology; Biochemistry, Molecular Biology; Biopsy; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; Colorectal cancer; CRISPR; Crohn Disease - microbiology; Crohn's disease; Cytokines - secretion; DNA, Bacterial - analysis; E coli; Epithelial Cells - microbiology; Escherichia coli; Escherichia coli - genetics; Escherichia coli - growth & development; Escherichia coli Infections - complications; Genome; Genomes; Genomics; Genotype & phenotype; Host-Pathogen Interactions; Human health and pathology; Humans; Hépatology and Gastroenterology; Inflammatory bowel disease; Interleukin-10 - secretion; Interleukin-6 - secretion; Interleukin-8 - secretion; Life Sciences; Macrophages - microbiology; Macrophages - secretion; Microbiology and Parasitology; Mutation; Nucleic acids; Phenotype; Phylogeny; Rodents; Sequence Analysis, DNA; Tumor Necrosis Factor-alpha - secretion; CROHN'S DISEASE; INTESTINAL MICROBIOLOGY; ENTERIC BACTERIAL MICROFLORA; intestinal microbiology; enteric bacterial microflora; Crohn's disease

ObjectiveAdherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to ide...