Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial

• Published in: BMJ (Online) Vol. 380; p. e072133
• Main Authors: Mao, Yan-Ping, Wang, Shun-Xin, Gao, Tian-Sheng, Zhang, Ning, Liang, Xiao-Yu, Xie, Fang-Yun, Zhang, Yuan, Zhou, Guan-Qun, Guo, Rui, Luo, Wei-Jie, Li, Yong-Jie, Liang, Shao-Qiang, Lin, Li, Li, Wen-Fei, Liu, Xu, Xu, Cheng, Chen, Yu-Pei, Lv, Jia-Wei, Huang, Shao-Hui, Liu, Li-Zhi, Li, Ji-Bin, Tang, Ling-Long, Chen, Lei, Sun, Ying, Ma, Jun
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 06.02.2023; BMJ Publishing Group LTD
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biopsy; Boundaries; Cancer therapies; Chemoradiotherapy; Chemotherapy; Clinical trials; Deglutition Disorders; Dysphagia; Humans; Lymph nodes; Lymph Nodes - pathology; Lymphatic system; Metastases; Metastasis; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - radiotherapy; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - radiotherapy; Neoplasm Recurrence, Local - radiotherapy; Patients; Planning; Public health; Quality of life; Radiation therapy; Regions; Survival; Survival analysis; Swallowing; Throat cancer; Toxicity

AbstractObjectivesTo address whether sparing the medial retropharyngeal lymph node (MRLN) region from elective irradiation volume provides non-inferior local relapse-free survival versus standard radiotherapy in patients with nasopharyngeal carcinoma.DesignOpen-label, non-inferiority, multicentre, r...