AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells

• Published in: Endocrine-related cancer Vol. 23; no. 5; pp. 433 - 443
• Main Authors: Lecoq, Anne-Lise, Viengchareun, Say, Hage, Mirella, Bouligand, Jérôme, Young, Jacques, Boutron, Audrey, Zizzari, Philippe, Lombès, Marc, Chanson, Philippe, Kamenický, Peter
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.05.2016
• Subjects: Adolescent; Adult; Animals; Basic Helix-Loop-Helix Transcription Factors - genetics; Cell Line; Cytochrome P-450 CYP1B1 - genetics; Female; Fibroblasts - metabolism; Humans; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Male; Mutation; Pituitary Neoplasms - genetics; Rats; Receptors, Aryl Hydrocarbon - genetics; Repressor Proteins - genetics; Signal Transduction; Young Adult; AIP; AhR; pituitary adenomas

Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas through unknown molecular mechanisms. The best-known interacting partner of AIP is the aryl hydrocarbon receptor (AhR), a transcription factor that mediates the effects of xenob...