Serial measurements of cardiac troponin I in heart failure secondary to canine mitral valve disease
Serial measurements of cardiac troponin I (cTnI) levels are considered to be better predictors of cardiac death than single-time-point analyses in human medicine. We hypothesised that cTnI levels could reflect the severity of myxomatous mitral valve disease (MMVD), and that serial changes in the cTn...
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| Published in | Veterinary record Vol. 185; no. 11; p. 343 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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BMJ Publishing Group Limited
01.09.2019
Blackwell Publishing Ltd |
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| Abstract | Serial measurements of cardiac troponin I (cTnI) levels are considered to be better predictors of cardiac death than single-time-point analyses in human medicine. We hypothesised that cTnI levels could reflect the severity of myxomatous mitral valve disease (MMVD), and that serial changes in the cTnI level had a prognostic value in dogs with congestive heart failure (CHF) secondary to MMVD. Seventy-six dogs were initially enrolled and classified by the American College of Veterinary Internal Medicine (ACVIM) staging system. The single-timepoint cTnI concentration in these dogs significantly increased with the ACVIM stage. Twenty-seven dogs with CHF subsequently underwent serial measurement of cTnI levels, and the results showed that those who demonstrated a decrease in cTnI levels from the first to the third visit exhibited a higher risk of cardiac death than did those without such changes (P=0.012). We suspect that the downward trend in cTnI levels may be affected by medical treatment for CHF. In conclusion, although cTnI levels could reflect the severity of MMVD to a certain extent, the serial changes may be affected by medical treatment. Therefore, caution should be exercised when cTnI is used for assessment of the prognosis of CHF secondary to MMVD in dogs. |
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| AbstractList | Serial measurements of cardiac troponin I (cTnI) levels are considered to be better predictors of cardiac death than single-time-point analyses in human medicine. We hypothesised that cTnI levels could reflect the severity of myxomatous mitral valve disease (MMVD), and that serial changes in the cTnI level had a prognostic value in dogs with congestive heart failure (CHF) secondary to MMVD. Seventy-six dogs were initially enrolled and classified by the American College of Veterinary Internal Medicine (ACVIM) staging system. The single-timepoint cTnI concentration in these dogs significantly increased with the ACVIM stage. Twenty-seven dogs with CHF subsequently underwent serial measurement of cTnI levels, and the results showed that those who demonstrated a decrease in cTnI levels from the first to the third visit exhibited a higher risk of cardiac death than did those without such changes (P=0.012). We suspect that the downward trend in cTnI levels may be affected by medical treatment for CHF. In conclusion, although cTnI levels could reflect the severity of MMVD to a certain extent, the serial changes may be affected by medical treatment. Therefore, caution should be exercised when cTnI is used for assessment of the prognosis of CHF secondary to MMVD in dogs. Serial measurements of cardiac troponin I (cTnI) levels are considered to be better predictors of cardiac death than single-time-point analyses in human medicine. We hypothesised that cTnI levels could reflect the severity of myxomatous mitral valve disease (MMVD), and that serial changes in the cTnI level had a prognostic value in dogs with congestive heart failure (CHF) secondary to MMVD. Seventy-six dogs were initially enrolled and classified by the American College of Veterinary Internal Medicine (ACVIM) staging system. The single-timepoint cTnI concentration in these dogs significantly increased with the ACVIM stage. Twenty-seven dogs with CHF subsequently underwent serial measurement of cTnI levels, and the results showed that those who demonstrated a decrease in cTnI levels from the first to the third visit exhibited a higher risk of cardiac death than did those without such changes (P=0.012). We suspect that the downward trend in cTnI levels may be affected by medical treatment for CHF. In conclusion, although cTnI levels could reflect the severity of MMVD to a certain extent, the serial changes may be affected by medical treatment. Therefore, caution should be exercised when cTnI is used for assessment of the prognosis of CHF secondary to MMVD in dogs.Serial measurements of cardiac troponin I (cTnI) levels are considered to be better predictors of cardiac death than single-time-point analyses in human medicine. We hypothesised that cTnI levels could reflect the severity of myxomatous mitral valve disease (MMVD), and that serial changes in the cTnI level had a prognostic value in dogs with congestive heart failure (CHF) secondary to MMVD. Seventy-six dogs were initially enrolled and classified by the American College of Veterinary Internal Medicine (ACVIM) staging system. The single-timepoint cTnI concentration in these dogs significantly increased with the ACVIM stage. Twenty-seven dogs with CHF subsequently underwent serial measurement of cTnI levels, and the results showed that those who demonstrated a decrease in cTnI levels from the first to the third visit exhibited a higher risk of cardiac death than did those without such changes (P=0.012). We suspect that the downward trend in cTnI levels may be affected by medical treatment for CHF. In conclusion, although cTnI levels could reflect the severity of MMVD to a certain extent, the serial changes may be affected by medical treatment. Therefore, caution should be exercised when cTnI is used for assessment of the prognosis of CHF secondary to MMVD in dogs. |
| Author | Wu, San-Yu Chan, I-Ping Chang, Chao-Chin Chen, Wen-Ying |
| Author_xml | – sequence: 1 givenname: I-Ping orcidid: 0000-0002-2407-5088 surname: Chan fullname: Chan, I-Ping email: wychen@dragon.nchu.edu.tw organization: Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan – sequence: 2 givenname: San-Yu surname: Wu fullname: Wu, San-Yu email: wychen@dragon.nchu.edu.tw organization: Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan – sequence: 3 givenname: Chao-Chin surname: Chang fullname: Chang, Chao-Chin email: wychen@dragon.nchu.edu.tw organization: Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung, Taiwan – sequence: 4 givenname: Wen-Ying surname: Chen fullname: Chen, Wen-Ying email: wychen@dragon.nchu.edu.tw organization: Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan |
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| Cites_doi | 10.1016/j.jvc.2012.02.001 10.1111/j.1939-1676.2003.tb01327.x 10.1111/j.1939-1676.2012.00894.x 10.2478/v10181-011-0082-z 10.1016/j.tvjl.2009.04.004 10.1111/j.1748-5827.2005.tb00304.x 10.1111/jvim.12075 10.1111/j.1939-1676.2000.tb02252.x 10.1111/vcp.12124 10.1111/vcp.12495 10.1111/j.1939-1676.2004.tb02551.x 10.1111/j.1748-5827.2009.00889.x 10.1111/j.1939-1676.1987.tb01999.x 10.1111/j.1939-1676.2009.0392.x 10.1016/j.jvc.2012.01.003 10.1111/jvim.15251 10.1111/j.1939-1676.2007.0008.x 10.1111/jsap.12265 10.1016/j.ahj.2011.07.007 10.1111/j.1939-1676.2011.0774.x 10.1111/j.1939-1676.2004.tb02629.x 10.1016/j.tvjl.2013.05.040 10.1111/jvim.14586 10.1111/j.1472-8206.2010.00854.x 10.1111/j.1939-1676.2007.tb03005.x 10.4142/jvs.2017.18.3.369 10.1111/j.1740-8261.2012.01976.x 10.1016/S0894-7317(03)00335-3 10.1111/joim.12756 10.1111/j.1939-1676.2008.0150.x 10.1016/S1760-2734(06)70047-9 10.1016/s0735-1097(97)00454-3 10.1111/j.1740-8261.2002.tb01051.x 10.1111/jvim.13801 10.2460/javma.1995.206.02.194 10.1016/S0735-1097(97)00454-3 10.7326/0003-4819-6-11-1371 |
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| Copyright | British Veterinary Association 2019. No commercial re-use. See rights and permissions. Published by BMJ. British Veterinary Association 2019 2019 British Veterinary Association 2019. No commercial re-use. See rights and permissions. Published by BMJ. |
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| Keywords | cardiac biomarkers degenerative mitral valve disease clinical outcomes tracking measurements |
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| References | Peddle, Singletary, Reynolds 2012; 14 Jepsen-Grant, Pollard, Johnson 2013; 54 Moonarmart, Boswood, Luis Fuentes 2010; 51 Kittleson, Johnson, Pion 1987; 1 Ljungvall, Höglund, Carnabuci 2011; 25 Oyama, Sisson 2004; 18 Buchanan, Bücheler 1995; 206 Fox 2012; 14 Cornell, Kittleson, Della Torre 2004; 18 Kittleson, Brown 20t03; 17 Ljungvall, Rishniw, Porciello 2014; 55 Kim, Han, Song 2017; 18 Borgarelli, Savarino, Crosara 2008; 22 Komukai, Mochizuki, Yoshimura 2010; 24 Polizopoulou, Koutinas, Dasopoulou 2014; 43 Brown, Atkins, Bagley 2007; 21 Petit, Gouni, Tissier 2013; 197 Kawahara, Tsutamoto, Sakai 2011; 162 Falk, Ljungvall, Zois 2013; 27 Noszczyk-Nowak 2011; 14 Langhorn, Willesen 2016; 30 Thomas, Foster, Schiller 1998; 31 Magnussen, Blankenberg 2018; 283 Zoghbi, Enriquez-Sarano, Foster 2003; 16 Atkins, Bonagura, Ettinger 2009; 23 Ljungvall, Höglund, Tidholm 2010; 24 Dukes-McEwan, Borgarelli, Tidholm 2003; 5 Freeman, Levine 1933; 6 Spratt, Mellanby, Drury 2005; 46 Häggström, Boswood, O'Grady 2008; 22 Winter, Saunders, Gordon 2017; 46 Hansson, Häggström, Kvart 2002; 43 Mattin, Boswood, Church 2019; 33 Fonfara, Loureiro, Swift 2010; 184 Boswood, Häggström, Gordon 2016; 30 Rishniw, Erb 2000; 14 Hezzell, Boswood, Chang 2012; 26 Kittleson, Eyster, Knowlen 1984; 184 2009; 23 1987; 1 2018; 283 2013; 27 1984; 184 2011 2019; 33 2017; 46 2016; 30 2003; 16 2010; 184 2011; 14 2012; 14 2014; 43 2005; 46 17 2010; 24 2004; 18 2000; 14 2013; 54 2002; 43 1995; 206 2003; 5 2008; 22 2017; 18 1933; 6 2012; 26 2013; 197 2011; 25 2011; 162 2007; 21 1998; 31 2010; 51 2014; 55 e_1_2_11_10_1 e_1_2_11_32_1 e_1_2_11_31_1 e_1_2_11_30_1 e_1_2_11_36_1 e_1_2_11_14_1 e_1_2_11_13_1 e_1_2_11_12_1 e_1_2_11_34_1 e_1_2_11_11_1 e_1_2_11_33_1 e_1_2_11_7_1 e_1_2_11_6_1 e_1_2_11_5_1 e_1_2_11_27_1 e_1_2_11_4_1 e_1_2_11_26_1 e_1_2_11_3_1 e_1_2_11_2_1 BOON JA (e_1_2_11_28_1) 2011 Ljungvall I (e_1_2_11_29_1) 2010; 24 e_1_2_11_21_1 e_1_2_11_20_1 e_1_2_11_25_1 e_1_2_11_40_1 e_1_2_11_24_1 e_1_2_11_9_1 e_1_2_11_23_1 e_1_2_11_8_1 e_1_2_11_22_1 e_1_2_11_18_1 e_1_2_11_17_1 e_1_2_11_16_1 Buchanan JW (e_1_2_11_19_1) 1995; 206 e_1_2_11_15_1 e_1_2_11_37_1 e_1_2_11_38_1 e_1_2_11_39_1 Kittleson MD (e_1_2_11_35_1) 1984; 184 31541051 - Vet Rec. 2019 Sep 21;185(11):340-342 |
| References_xml | – volume: 14 start-page: 103 year: 2012 article-title: Pathology of myxomatous mitral valve disease in the dog publication-title: J Vet Cardiol doi: 10.1016/j.jvc.2012.02.001 – volume: 17 start-page: 84 year: 20t03 article-title: Regurgitant fraction measured by using the proximal isovelocity surface area method in dogs with chronic myxomatous mitral valve disease publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2003.tb01327.x – volume: 26 start-page: 302 year: 2012 article-title: The combined prognostic potential of serum high-sensitivity cardiac troponin I and N-terminal pro-B-type natriuretic peptide concentrations in dogs with degenerative mitral valve disease publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2012.00894.x – volume: 14 start-page: 551 year: 2011 article-title: NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure publication-title: Pol J Vet Sci doi: 10.2478/v10181-011-0082-z – volume: 184 start-page: 334 year: 2010 article-title: Cardiac troponin I as a marker for severity and prognosis of cardiac disease in dogs publication-title: Vet J doi: 10.1016/j.tvjl.2009.04.004 – volume: 46 start-page: 139 year: 2005 article-title: Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog publication-title: J Small Anim Pract doi: 10.1111/j.1748-5827.2005.tb00304.x – volume: 27 start-page: 500 year: 2013 article-title: Cardiac troponin-I concentration, myocardial arteriosclerosis, and fibrosis in dogs with congestive heart failure because of myxomatous mitral valve disease publication-title: J Vet Intern Med doi: 10.1111/jvim.12075 – volume: 14 start-page: 429 year: 2000 article-title: Evaluation of four 2-Dimensional echocardiographic methods of assessing left atrial size in dogs publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2000.tb02252.x – volume: 43 start-page: 218 year: 2014 article-title: Serial analysis of serum cardiac troponin I changes and correlation with clinical findings in 46 dogs with mitral valve disease publication-title: Vet Clin Pathol doi: 10.1111/vcp.12124 – volume: 46 start-page: 299 year: 2017 article-title: Biologic variability of cardiac troponin I in healthy dogs and dogs with different stages of myxomatous mitral valve disease using standard and high-sensitivity immunoassays publication-title: Vet Clin Pathol doi: 10.1111/vcp.12495 – volume: 24 start-page: 153 year: 2010 article-title: Cardiac troponin I is associated with severity of myxomatous mitral valve disease, age, and C‐reactive protein in dogs publication-title: Vet Clin Pathol – volume: 18 start-page: 311 year: 2004 article-title: Allometric scaling of M-mode cardiac measurements in normal adult dogs publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2004.tb02551.x – volume: 51 start-page: 84 year: 2010 article-title: N-Terminal pro B-type natriuretic peptide and left ventricular diameter independently predict mortality in dogs with mitral valve disease publication-title: J Small Anim Pract doi: 10.1111/j.1748-5827.2009.00889.x – volume: 1 start-page: 121 year: 1987 article-title: The acute hemodynamic effects of milrinone in dogs with severe idiopathic myocardial failure publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.1987.tb01999.x – volume: 23 start-page: 1142 year: 2009 article-title: Guidelines for the diagnosis and treatment of canine chronic valvular heart disease publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2009.0392.x – volume: 14 start-page: 253 year: 2012 article-title: Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease publication-title: J Vet Cardiol doi: 10.1016/j.jvc.2012.01.003 – volume: 33 start-page: 432 year: 2019 article-title: Prognostic factors in dogs with presumed degenerative mitral valve disease attending primary-care veterinary practices in the United Kingdom publication-title: J Vet Intern Med doi: 10.1111/jvim.15251 – volume: 22 start-page: 120 year: 2008 article-title: Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2007.0008.x – volume: 55 start-page: 545 year: 2014 article-title: Murmur intensity in small-breed dogs with myxomatous mitral valve disease reflects disease severity publication-title: J Small Anim Pract doi: 10.1111/jsap.12265 – volume: 162 start-page: 639 year: 2011 article-title: Prognostic value of serial measurements of highly sensitive cardiac troponin I in stable outpatients with nonischemic chronic heart failure publication-title: Am Heart J doi: 10.1016/j.ahj.2011.07.007 – volume: 25 start-page: 1036 year: 2011 article-title: Assessment of global and regional left ventricular volume and shape by real-time 3-dimensional echocardiography in dogs with myxomatous mitral valve disease publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2011.0774.x – volume: 18 start-page: 831 year: 2004 article-title: Cardiac troponin-I concentration in dogs with cardiac disease publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2004.tb02629.x – volume: 197 start-page: 830 year: 2013 article-title: Systolic arterial blood pressure in small-breed dogs with degenerative mitral valve disease: a prospective study of 103 cases (2007-2012) publication-title: Vet J doi: 10.1016/j.tvjl.2013.05.040 – volume: 30 start-page: 1765 year: 2016 article-title: Effect of pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: the EPIC Study-A randomized clinical trial publication-title: J Vet Intern Med doi: 10.1111/jvim.14586 – volume: 24 start-page: 687 year: 2010 article-title: Gender and the renin-angiotensin-aldosterone system publication-title: Fundam Clin Pharmacol doi: 10.1111/j.1472-8206.2010.00854.x – volume: 206 start-page: 194 year: 1995 article-title: Vertebral scale system to measure canine heart size in radiographs publication-title: J Am Vet Med Assoc – volume: 21 start-page: 542 year: 2007 article-title: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2007.tb03005.x – volume: 18 start-page: 369 year: 2017 article-title: Retrospective study of degenerative mitral valve disease in small-breed dogs: survival and prognostic variables publication-title: J Vet Sci doi: 10.4142/jvs.2017.18.3.369 – volume: 54 start-page: 3 year: 2013 article-title: Vertebral heart scores in eight dog breeds publication-title: Vet Radiol Ultrasound doi: 10.1111/j.1740-8261.2012.01976.x – volume: 16 start-page: 777 year: 2003 article-title: Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography publication-title: J Am Soc Echocardiogr doi: 10.1016/S0894-7317(03)00335-3 – volume: 283 start-page: 530 year: 2018 article-title: Biomarkers for heart failure: small molecules with high clinical relevance publication-title: J Intern Med doi: 10.1111/joim.12756 – volume: 22 start-page: 1124 year: 2008 article-title: Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the quest study publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2008.0150.x – volume: 5 start-page: 7 year: 2003 article-title: Proposed guidelines for the diagnosis of canine idiopathic dilated cardiomyopathy publication-title: J Vet Cardiol doi: 10.1016/S1760-2734(06)70047-9 – volume: 184 start-page: 455 year: 1984 article-title: Myocardial function in small dogs with chronic mitral regurgitation and severe congestive heart failure publication-title: J Am Vet Med Assoc – volume: 31 start-page: 174 year: 1998 article-title: Peak mitral inflow velocity predicts mitral regurgitation severity publication-title: J Am Coll Cardiol doi: 10.1016/s0735-1097(97)00454-3 – volume: 6 start-page: 1371 year: 1933 article-title: The clinical significance of the systolic murmur: a study of 1000 consecutive non-cardiac cases publication-title: Ann Intern Med – volume: 43 start-page: 568 year: 2002 article-title: Left atrial to aortic root indices using two-dimensional and M-mode echocardiography in cavalier King Charles spaniels with and without left atrial enlargement publication-title: Vet Radiol Ultrasound doi: 10.1111/j.1740-8261.2002.tb01051.x – volume: 30 start-page: 36 year: 2016 article-title: Cardiac troponins in dogs and cats publication-title: J Vet Intern Med doi: 10.1111/jvim.13801 – volume: 30 start-page: 1765 year: 2016 end-page: 79 article-title: Effect of pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: the EPIC Study‐A randomized clinical trial publication-title: J Vet Intern Med – volume: 6 start-page: 1371 year: 1933 end-page: 85 article-title: The clinical significance of the systolic murmur: a study of 1000 consecutive non‐cardiac cases publication-title: Ann Intern Med – volume: 51 start-page: 84 year: 2010 end-page: 96 article-title: N‐Terminal pro B‐type natriuretic peptide and left ventricular diameter independently predict mortality in dogs with mitral valve disease publication-title: J Small Anim Pract – start-page: 153 year: 2011 end-page: 266 – volume: 184 start-page: 334 year: 2010 end-page: 9 article-title: Cardiac troponin I as a marker for severity and prognosis of cardiac disease in dogs publication-title: Vet J – volume: 21 start-page: 542 year: 2007 end-page: 58 article-title: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats publication-title: J Vet Intern Med – volume: 283 start-page: 530 year: 2018 end-page: 43 article-title: Biomarkers for heart failure: small molecules with high clinical relevance publication-title: J Intern Med – volume: 1 start-page: 121 year: 1987 end-page: 7 article-title: The acute hemodynamic effects of milrinone in dogs with severe idiopathic myocardial failure publication-title: J Vet Intern Med – volume: 23 start-page: 1142 year: 2009 end-page: 50 article-title: Guidelines for the diagnosis and treatment of canine chronic valvular heart disease publication-title: J Vet Intern Med – volume: 54 start-page: 3 year: 2013 end-page: 8 article-title: Vertebral heart scores in eight dog breeds publication-title: Vet Radiol Ultrasound – volume: 206 start-page: 194 year: 1995 end-page: 9 article-title: Vertebral scale system to measure canine heart size in radiographs publication-title: J Am Vet Med Assoc – volume: 14 start-page: 103 year: 2012 end-page: 26 article-title: Pathology of myxomatous mitral valve disease in the dog publication-title: J Vet Cardiol – volume: 14 start-page: 253 year: 2012 end-page: 9 article-title: Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease publication-title: J Vet Cardiol – volume: 18 start-page: 369 year: 2017 end-page: 76 article-title: Retrospective study of degenerative mitral valve disease in small‐breed dogs: survival and prognostic variables publication-title: J Vet Sci – volume: 27 start-page: 500 year: 2013 end-page: 6 article-title: Cardiac troponin‐I concentration, myocardial arteriosclerosis, and fibrosis in dogs with congestive heart failure because of myxomatous mitral valve disease publication-title: J Vet Intern Med – volume: 24 start-page: 153 year: 2010 end-page: 9 article-title: Cardiac troponin I is associated with severity of myxomatous mitral valve disease, age, and C‐reactive protein in dogs publication-title: Vet Clin Pathol – volume: 24 start-page: 687 year: 2010 end-page: 98 article-title: Gender and the renin‐angiotensin‐aldosterone system publication-title: Fundam Clin Pharmacol – volume: 16 start-page: 777 year: 2003 end-page: 802 article-title: Recommendations for evaluation of the severity of native valvular regurgitation with two‐dimensional and Doppler echocardiography publication-title: J Am Soc Echocardiogr – volume: 30 start-page: 36 year: 2016 end-page: 50 article-title: Cardiac troponins in dogs and cats publication-title: J Vet Intern Med – volume: 31 start-page: 174 year: 1998 end-page: 9 article-title: Peak mitral inflow velocity predicts mitral regurgitation severity publication-title: J Am Coll Cardiol – volume: 18 start-page: 831 year: 2004 end-page: 9 article-title: Cardiac troponin‐I concentration in dogs with cardiac disease publication-title: J Vet Intern Med – volume: 43 start-page: 568 year: 2002 end-page: 75 article-title: Left atrial to aortic root indices using two‐dimensional and M‐mode echocardiography in cavalier King Charles spaniels with and without left atrial enlargement publication-title: Vet Radiol Ultrasound – volume: 55 start-page: 545 year: 2014 end-page: 50 article-title: Murmur intensity in small‐breed dogs with myxomatous mitral valve disease reflects disease severity publication-title: J Small Anim Pract – volume: 162 start-page: 639 year: 2011 end-page: 45 article-title: Prognostic value of serial measurements of highly sensitive cardiac troponin I in stable outpatients with nonischemic chronic heart failure publication-title: Am Heart J – volume: 46 start-page: 299 year: 2017 end-page: 307 article-title: Biologic variability of cardiac troponin I in healthy dogs and dogs with different stages of myxomatous mitral valve disease using standard and high‐sensitivity immunoassays publication-title: Vet Clin Pathol – volume: 46 start-page: 139 year: 2005 end-page: 45 article-title: Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog publication-title: J Small Anim Pract – volume: 26 start-page: 302 year: 2012 end-page: 11 article-title: The combined prognostic potential of serum high‐sensitivity cardiac troponin I and N‐terminal pro‐B‐type natriuretic peptide concentrations in dogs with degenerative mitral valve disease publication-title: J Vet Intern Med – volume: 43 start-page: 218 year: 2014 end-page: 25 article-title: Serial analysis of serum cardiac troponin I changes and correlation with clinical findings in 46 dogs with mitral valve disease publication-title: Vet Clin Pathol – volume: 22 start-page: 120 year: 2008 end-page: 8 article-title: Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease publication-title: J Vet Intern Med – volume: 14 start-page: 551 year: 2011 end-page: 6 article-title: NT‐pro‐BNP and troponin I as predictors of mortality in dogs with heart failure publication-title: Pol J Vet Sci – volume: 5 start-page: 7 year: 2003 end-page: 19 article-title: Proposed guidelines for the diagnosis of canine idiopathic dilated cardiomyopathy publication-title: J Vet Cardiol – volume: 22 start-page: 1124 year: 2008 end-page: 35 article-title: Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the quest study publication-title: J Vet Intern Med – volume: 184 start-page: 455 year: 1984 end-page: 9 article-title: Myocardial function in small dogs with chronic mitral regurgitation and severe congestive heart failure publication-title: J Am Vet Med Assoc – volume: 197 start-page: 830 year: 2013 end-page: 5 article-title: Systolic arterial blood pressure in small‐breed dogs with degenerative mitral valve disease: a prospective study of 103 cases (2007‐2012) publication-title: Vet J – volume: 18 start-page: 311 year: 2004 end-page: 21 article-title: Allometric scaling of M‐mode cardiac measurements in normal adult dogs publication-title: J Vet Intern Med – volume: 33 start-page: 432 year: 2019 end-page: 44 article-title: Prognostic factors in dogs with presumed degenerative mitral valve disease attending primary‐care veterinary practices in the United Kingdom publication-title: J Vet Intern Med – volume: 14 start-page: 429 year: 2000 end-page: 35 article-title: Evaluation of four 2‐Dimensional echocardiographic methods of assessing left atrial size in dogs publication-title: J Vet Intern Med – volume: 17 start-page: 84 end-page: 8 article-title: Regurgitant fraction measured by using the proximal isovelocity surface area method in dogs with chronic myxomatous mitral valve disease publication-title: J Vet Intern Med – volume: 25 start-page: 1036 year: 2011 end-page: 43 article-title: Assessment of global and regional left ventricular volume and shape by real‐time 3‐dimensional echocardiography in dogs with myxomatous mitral valve disease publication-title: J Vet Intern Med – ident: e_1_2_11_13_1 doi: 10.1016/j.tvjl.2009.04.004 – ident: e_1_2_11_23_1 doi: 10.1111/j.1939-1676.2007.tb03005.x – ident: e_1_2_11_20_1 doi: 10.1111/j.1748-5827.2009.00889.x – volume: 206 start-page: 194 year: 1995 ident: e_1_2_11_19_1 article-title: Vertebral scale system to measure canine heart size in radiographs publication-title: J Am Vet Med Assoc doi: 10.2460/javma.1995.206.02.194 – ident: e_1_2_11_9_1 doi: 10.1111/j.1472-8206.2010.00854.x – ident: e_1_2_11_5_1 doi: 10.4142/jvs.2017.18.3.369 – ident: e_1_2_11_16_1 doi: 10.1111/vcp.12124 – ident: e_1_2_11_38_1 doi: 10.1111/j.1939-1676.2003.tb01327.x – ident: e_1_2_11_33_1 doi: 10.1111/jsap.12265 – ident: e_1_2_11_15_1 doi: 10.1016/j.ahj.2011.07.007 – ident: e_1_2_11_14_1 doi: 10.1111/joim.12756 – ident: e_1_2_11_10_1 doi: 10.1111/jvim.12075 – ident: e_1_2_11_27_1 doi: 10.1111/j.1740-8261.2002.tb01051.x – ident: e_1_2_11_12_1 doi: 10.1111/j.1939-1676.2004.tb02629.x – volume: 184 start-page: 455 year: 1984 ident: e_1_2_11_35_1 article-title: Myocardial function in small dogs with chronic mitral regurgitation and severe congestive heart failure publication-title: J Am Vet Med Assoc – ident: e_1_2_11_34_1 doi: 10.1111/j.1939-1676.1987.tb01999.x – ident: e_1_2_11_11_1 doi: 10.1111/jvim.13801 – ident: e_1_2_11_7_1 doi: 10.1111/j.1939-1676.2012.00894.x – ident: e_1_2_11_32_1 doi: 10.1016/S0735-1097(97)00454-3 – ident: e_1_2_11_40_1 doi: 10.1111/jvim.15251 – ident: e_1_2_11_3_1 doi: 10.1016/j.jvc.2012.02.001 – start-page: 153 volume-title: Veterinary echocardiography year: 2011 ident: e_1_2_11_28_1 – ident: e_1_2_11_2_1 doi: 10.1111/j.1939-1676.2009.0392.x – ident: e_1_2_11_25_1 doi: 10.1111/j.1740-8261.2012.01976.x – ident: e_1_2_11_30_1 doi: 10.1111/j.1748-5827.2005.tb00304.x – ident: e_1_2_11_36_1 doi: 10.1016/j.tvjl.2013.05.040 – ident: e_1_2_11_39_1 doi: 10.1111/jvim.14586 – ident: e_1_2_11_18_1 doi: 10.1016/S1760-2734(06)70047-9 – ident: e_1_2_11_26_1 doi: 10.1111/j.1939-1676.2004.tb02551.x – ident: e_1_2_11_37_1 doi: 10.1111/j.1939-1676.2011.0774.x – ident: e_1_2_11_24_1 doi: 10.1016/j.jvc.2012.01.003 – ident: e_1_2_11_6_1 doi: 10.1111/j.1939-1676.2007.0008.x – ident: e_1_2_11_22_1 doi: 10.7326/0003-4819-6-11-1371 – ident: e_1_2_11_4_1 doi: 10.1111/j.1939-1676.2008.0150.x – volume: 24 start-page: 153 year: 2010 ident: e_1_2_11_29_1 article-title: Cardiac troponin I is associated with severity of myxomatous mitral valve disease, age, and C‐reactive protein in dogs publication-title: Vet Clin Pathol – ident: e_1_2_11_21_1 doi: 10.1111/j.1939-1676.2000.tb02252.x – ident: e_1_2_11_17_1 doi: 10.1111/vcp.12495 – ident: e_1_2_11_8_1 doi: 10.2478/v10181-011-0082-z – ident: e_1_2_11_31_1 doi: 10.1016/S0894-7317(03)00335-3 – reference: 31541051 - Vet Rec. 2019 Sep 21;185(11):340-342 |
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| Snippet | Serial measurements of cardiac troponin I (cTnI) levels are considered to be better predictors of cardiac death than single-time-point analyses in human... Serial measurements of cardiac troponin I (cTnI) levels are considered to be better predictors of cardiac death than single‐time‐point analyses in human... |
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| SubjectTerms | Biomarkers Blood pressure cardiac biomarkers clinical outcomes Coronary vessels death degenerative mitral valve disease Disease Dogs Edema Electrocardiography Heart failure Internal medicine Medical prognosis medical treatment medicine Peptides prognosis Radiography risk Studies tracking measurements Ultrasonic imaging Veterinary medicine |
| Title | Serial measurements of cardiac troponin I in heart failure secondary to canine mitral valve disease |
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