A proton NMR study of the effect of a new intravasal injectable male contraceptive RISUG on seminal plasma metabolites

• Published in: Reproduction (Cambridge, England) Vol. 122; no. 3; pp. 431 - 436
• Main Authors: Sharma, U, Chaudhury, K, Jagannathan, NR, Guha, SK
• Format: Journal Article
• Language: English
• Published: Colchester Society for Reproduction and Fertility 01.09.2001; Portland
• Subjects: Adult; Biological and medical sciences; Birth control; Choline - analysis; Choline - metabolism; Citric Acid - analysis; Citric Acid - metabolism; Contraceptive Agents, Male - administration & dosage; Contraceptive Agents, Male - pharmacology; Dimethyl Sulfoxide - administration & dosage; Dimethyl Sulfoxide - pharmacology; Glucose - analysis; Glucose - metabolism; Glycerylphosphorylcholine - analysis; Glycerylphosphorylcholine - metabolism; Gynecology. Andrology. Obstetrics; Humans; Injections; Lactic Acid - analysis; Lactic Acid - metabolism; Magnetic Resonance Spectroscopy; Male; Maleates - administration & dosage; Maleates - pharmacology; Medical sciences; Other methods of contraception. Sterilization; Polyesters; Polystyrenes; Prostate - drug effects; Prostate - physiology; Semen - metabolism; Styrenes - administration & dosage; Styrenes - pharmacology; Human; Semen pathway; Semen; Metabolite; Toxicity; Male; Male genital duct; Route of administration; Vas deferens; Maleic anhydride polymer; Styrene polymer; Contraceptive; Seminal plasma
• ISSN: 1470-1626; 1741-7899
• DOI: 10.1530/rep.0.1220431

Nuclear magnetic resonance (NMR) spectroscopy was used to quantify citrate, glucose, lactate, glycerophosphorylcholine and choline in seminal plasma from subjects injected with a new male contraceptive RISUG, a copolymer of styrene maleic anhydride dissolved in dimethyl sulphoxide, and in seminal pl...