Identifying a hyperinflammatory subphenotype of ARDS associated with worse outcomes: may ferritin help?
[...]measurement of those biomarkers can only be undertaken in the research laboratory setting. [...]it would be desirable if, instead of multiple biomarkers, a single marker that is routinely available in the clinical setting could be used to stratify patients and, specifically, identify patients w...
Saved in:
Published in | Thorax Vol. 79; no. 3; pp. 200 - 201 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
BMJ Publishing Group Ltd and British Thoracic Society
29.01.2024
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | [...]measurement of those biomarkers can only be undertaken in the research laboratory setting. [...]it would be desirable if, instead of multiple biomarkers, a single marker that is routinely available in the clinical setting could be used to stratify patients and, specifically, identify patients with ARDS at risk for worse outcomes. [...]the authors performed a mediation analysis demonstrating that the association between ferritin and mortality was mediated by interleukin (IL) 18 to a small but statistically significant effect, after adjustment for confounders, such as aetiology of ARDS and APACHE II Score. [...]the authors selected a single and widely available in the clinical practice marker (namely, ferritin) to identify patients with ARDS at risk for high mortality. Data regarding the trajectories of subphenotypes in critical illness is limited so far.16 One study extended latent class analysis in two RCTs of patients with ARDS on day 3, where two subphenotypes were again evident.17 That study found that >94% of patients stayed in their corresponding subphenotype class on day 3.17 However, whether the inflammatory burden and disease implications of the subphenotypes identified at baseline and day 3 are the same is unknown.18 Use of trajectory data will be of critical importance in future studies to gain deeper understanding of the temporal kinetics of a particular subphenotype, as well as whether disease states may be modified by treatment. |
---|---|
AbstractList | [...]measurement of those biomarkers can only be undertaken in the research laboratory setting. [...]it would be desirable if, instead of multiple biomarkers, a single marker that is routinely available in the clinical setting could be used to stratify patients and, specifically, identify patients with ARDS at risk for worse outcomes. [...]the authors performed a mediation analysis demonstrating that the association between ferritin and mortality was mediated by interleukin (IL) 18 to a small but statistically significant effect, after adjustment for confounders, such as aetiology of ARDS and APACHE II Score. [...]the authors selected a single and widely available in the clinical practice marker (namely, ferritin) to identify patients with ARDS at risk for high mortality. Data regarding the trajectories of subphenotypes in critical illness is limited so far.16 One study extended latent class analysis in two RCTs of patients with ARDS on day 3, where two subphenotypes were again evident.17 That study found that >94% of patients stayed in their corresponding subphenotype class on day 3.17 However, whether the inflammatory burden and disease implications of the subphenotypes identified at baseline and day 3 are the same is unknown.18 Use of trajectory data will be of critical importance in future studies to gain deeper understanding of the temporal kinetics of a particular subphenotype, as well as whether disease states may be modified by treatment. |
Author | Siempos, Ilias I Torres, Lisa K |
Author_xml | – sequence: 1 givenname: Lisa K orcidid: 0000-0001-5124-0395 surname: Torres fullname: Torres, Lisa K organization: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, New York, USA – sequence: 2 givenname: Ilias I orcidid: 0000-0003-0036-3322 surname: Siempos fullname: Siempos, Ilias I email: isiempos@yahoo.com organization: First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38286617$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kUtr3TAQRkVJaW5u-we6KIJusnGqkRzJ6qaE9BUIFPpYm7Esx7rYkivJpP739cVpC11kNTBz5puBc0ZOfPCWkJfALgCEfJP7EPFXwRkXBedrC56QHZSyKgTX8oTsGCtZIYWSp-QspQNjrAJQz8ipqHglJagdubtprc-uW5y_o0j7ZbLR-W7AccQc4kLT3Ey99SGvExo6evX1_TeKKQXjMNuW3rvc0_sQ0zqdswmjTW_piAvtbIwuO097O0zvnpOnHQ7Jvnioe_Lj44fv15-L2y-fbq6vbotGaJELsAqVMJ3uoLGAjVJdqau2NQiMg1a2xEpqzbS5rNACR2Y4GtPKkgEXeCn25HzLnWL4OduU69ElY4cBvQ1zqrnmDCql12t78vo_9BDm6NfvjpQsBWclf5wCXQqtxJHiG2ViSCnarp6iGzEuNbD6KKveZNVHWfUma1169RA9N6Nt_678sbMCFxvQjId_Zx9J_A3qsqHe |
Cites_doi | 10.1038/s41435-023-00217-8 10.3389/fimmu.2022.919973 10.1164/rccm.201201-0003OC 10.1056/NEJMoa1901686 10.1136/thorax-2023-220262 10.1146/annurev-med-043021-014005 10.1186/s13054-022-04071-4 10.1136/thoraxjnl-2017-211090 10.1016/S0140-6736(22)01439-8 10.1007/s00134-023-07244-z 10.1002/pbc.21039 10.1136/thoraxjnl-2020-215950 10.1038/s41598-020-69031-w 10.1016/S2665-9913(20)30343-X 10.1016/j.xcrm.2022.100817 10.1136/thorax-2023-220292 10.1136/thoraxjnl-2021-217158 10.1038/s41591-023-02617-9 10.1056/NEJMoa1403285 10.1111/cts.12538 10.1136/thorax-2023-220455 |
ContentType | Journal Article |
Copyright | Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. 2024 Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. |
Copyright_xml | – notice: Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. – notice: 2024 Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA BENPR BTHHO CCPQU FYUFA GHDGH K9. M0S M1P PQEST PQQKQ PQUKI 7X8 |
DOI | 10.1136/thorax-2023-221131 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central AUTh Library subscriptions: ProQuest Central BMJ Journals ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest Medical Library ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) BMJ Journals ProQuest One Academic ProQuest Medical Library (Alumni) ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | ProQuest One Academic Eastern Edition ProQuest One Academic Eastern Edition |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 7X7 name: ProQuest Health & Medical Collection url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1468-3296 |
EndPage | 201 |
ExternalDocumentID | 10_1136_thorax_2023_221131 38286617 ttps://thorax.bmj.com/content/79/3/200.full |
Genre | Editorial Commentary |
GrantInformation_xml | – fundername: National Institutes of Health grantid: K23 GM151730-01 funderid: http://dx.doi.org/10.13039/100000002 – fundername: Hellenic Foundation for Research and Innovation grantid: 80- 1/15.10.2020 funderid: http://dx.doi.org/10.13039/501100013209 – fundername: NIGMS NIH HHS grantid: K23 GM151730 |
GroupedDBID | --- .55 .VT 08G 0R~ 123 18M 29Q 39C 4.4 40O 5RE 5VS 6PF 7X7 7~S 88E 8F7 8FI 8FJ AAHLL AAOJX AAWJN AAWTL AAYEP ABAAH ABJNI ABKDF ABMQD ABOCM ABTFR ABUWG ABVAJ ACGFO ACGFS ACGTL ACHTP ACMFJ ACOFX ACTZY ADBBV AENEX AFKRA AFWFF AHMBA AHNKE AHQMW AJYBZ ALIPV ALMA_UNASSIGNED_HOLDINGS BENPR BLJBA BOMFT BPHCQ BTFSW BTHHO BVXVI CCPQU CS3 CXRWF DU5 EBS F5P FYUFA GX1 H13 HAJ HMCUK HZ~ IAO IEA IH2 IHR IOF KQ8 L7B M1P N9A NXWIF O9- OVD P2P PQQKQ PROAC PSQYO RHF RHI RMJ RPM RV8 TEORI UAW UKHRP UYXKK V24 VVN WH7 X7M YFH YOC YQY CGR CUY CVF ECM EIF NPM .GJ 2WC 354 3O- 3V. 53G 8R4 8R5 AAKAS AAYXX ADCEG ADZCM ASPBG AVWKF AZFZN BAWUL C45 CAG CITATION COF DIK E3Z EJD FEDTE HVGLF HYE ITC J5H N4W NTWIH OK1 Q2X R53 TR2 VM9 W8F ZCG ZGI 7XB 8FK K9. PQEST PQUKI 7X8 |
ID | FETCH-LOGICAL-b393t-1e7a73cf9f1be1ab77f498ddca102197e4a869909c58ae12a0c2accd640123a53 |
IEDL.DBID | BENPR |
ISSN | 0040-6376 |
IngestDate | Sat Aug 17 05:41:03 EDT 2024 Fri Sep 13 09:18:59 EDT 2024 Thu Aug 29 22:19:09 EDT 2024 Fri Aug 23 01:37:21 EDT 2024 Sat Sep 28 08:13:25 EDT 2024 Wed Aug 21 01:59:24 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Keywords | Critical Care ARDS Hypoxemia |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-b393t-1e7a73cf9f1be1ab77f498ddca102197e4a869909c58ae12a0c2accd640123a53 |
Notes | SourceType-Other Sources-1 content type line 63 ObjectType-Editorial-2 ObjectType-Commentary-1 |
ORCID | 0000-0001-5124-0395 0000-0003-0036-3322 |
OpenAccessLink | https://doi.org/10.1136/thorax-2023-221131 |
PMID | 38286617 |
PQID | 2919439732 |
PQPubID | 2041050 |
PageCount | 2 |
ParticipantIDs | proquest_miscellaneous_2920187939 proquest_journals_2926432042 proquest_journals_2919439732 crossref_primary_10_1136_thorax_2023_221131 pubmed_primary_38286617 bmj_journals_10_1136_thorax_2023_221131 |
PublicationCentury | 2000 |
PublicationDate | 2024-01-29 |
PublicationDateYYYYMMDD | 2024-01-29 |
PublicationDate_xml | – month: 01 year: 2024 text: 2024-01-29 day: 29 |
PublicationDecade | 2020 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: London |
PublicationTitle | Thorax |
PublicationTitleAbbrev | Thorax |
PublicationTitleAlternate | Thorax |
PublicationYear | 2024 |
Publisher | BMJ Publishing Group Ltd and British Thoracic Society BMJ Publishing Group LTD |
Publisher_xml | – name: BMJ Publishing Group Ltd and British Thoracic Society – name: BMJ Publishing Group LTD |
References | Dolinay, Kim, Howrylak (R11) 2012; 185 Xu, Mao, Su (R16) 2022; 26 Shakhnovich (R19) 2018; 11 Gorman, O’Kane, McAuley (R3) 2022; 400 Ruscitti, Di Benedetto, Berardicurti (R10) 2020; 10 Torres, Hoffman, Oromendia (R1) 2021; 76 Mehta, Samanta, Wick (R7) 2024; 79 Vanmeerbeek, Naulaerts, Garg (R20) 2023; 24 Redaelli, von Wedel, Fosset (R5) 2023; 49 Sinha, Meyer, Calfee (R18) 2023; 74 Sinha, Delucchi, Chen (R6) 2022; 77 Delucchi, Famous, Ware (R17) 2018; 73 Leventogiannis, Kyriazopoulou, Antonakos (R13) 2022; 3 Saha, Pham, Sinha (R2) 2023; 78 Henter, Horne, Aricó (R12) 2007; 48 Montassier, Kitsios, Radder (R4) 2023; 29 Webb, Peltan, Jensen (R14) 2020; 2 Moss, Huang, Brower (R9) 2019; 380 McAuley, Laffey, O’Kane (R8) 2014; 371 Ihim, Abubakar, Zian (R15) 2022; 13 Ihim (2024032819550881000_79.3.200.15) 2022; 13 Redaelli (2024032819550881000_79.3.200.5) 2023; 49 Vanmeerbeek (2024032819550881000_79.3.200.20) 2023; 24 Ruscitti (2024032819550881000_79.3.200.10) 2020; 10 Sinha (2024032819550881000_79.3.200.18) 2023; 74 Montassier (2024032819550881000_79.3.200.4) 2023; 29 Xu (2024032819550881000_79.3.200.16) 2022; 26 2024032819550881000_79.3.200.1 2024032819550881000_79.3.200.2 2024032819550881000_79.3.200.7 Webb (2024032819550881000_79.3.200.14) 2020; 2 2024032819550881000_79.3.200.6 2024032819550881000_79.3.200.9 2024032819550881000_79.3.200.12 2024032819550881000_79.3.200.8 2024032819550881000_79.3.200.11 Leventogiannis (2024032819550881000_79.3.200.13) 2022; 3 Gorman (2024032819550881000_79.3.200.3) 2022; 400 2024032819550881000_79.3.200.17 2024032819550881000_79.3.200.19 |
References_xml | – volume: 24 start-page: 217 year: 2023 ident: R20 article-title: Reverse translation: the key to increasing the clinical success of Immunotherapy publication-title: Genes Immun doi: 10.1038/s41435-023-00217-8 contributor: fullname: Garg – volume: 13 year: 2022 ident: R15 article-title: Interleukin-18 cytokine in immunity, inflammation, and Autoimmunity: biological role in induction, regulation, and treatment publication-title: Front Immunol doi: 10.3389/fimmu.2022.919973 contributor: fullname: Zian – volume: 185 start-page: 1225 year: 2012 ident: R11 article-title: Inflammasome-regulated Cytokines are critical mediators of acute lung injury publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201201-0003OC contributor: fullname: Howrylak – volume: 380 start-page: 1997 year: 2019 ident: R9 article-title: Early neuromuscular blockade in the acute respiratory distress syndrome publication-title: N Engl J Med doi: 10.1056/NEJMoa1901686 contributor: fullname: Brower – volume: 78 start-page: 990 year: 2023 ident: R2 article-title: Estimating the attributable fraction of mortality from acute respiratory distress syndrome to inform enrichment in future randomised clinical trials publication-title: Thorax doi: 10.1136/thorax-2023-220262 contributor: fullname: Sinha – volume: 74 start-page: 457 year: 2023 ident: R18 article-title: Biological Phenotyping in sepsis and acute respiratory distress syndrome publication-title: Annu Rev Med doi: 10.1146/annurev-med-043021-014005 contributor: fullname: Calfee – volume: 26 year: 2022 ident: R16 article-title: Sepsis Subphenotyping based on organ dysfunction trajectory publication-title: Crit Care doi: 10.1186/s13054-022-04071-4 contributor: fullname: Su – volume: 73 start-page: 439 year: 2018 ident: R17 article-title: Stability of ARDS Subphenotypes over time in two randomised controlled trials publication-title: Thorax doi: 10.1136/thoraxjnl-2017-211090 contributor: fullname: Ware – volume: 400 start-page: 1157 year: 2022 ident: R3 article-title: Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management publication-title: Lancet doi: 10.1016/S0140-6736(22)01439-8 contributor: fullname: McAuley – volume: 49 start-page: 1499 year: 2023 ident: R5 article-title: Inflammatory Subphenotypes in patients at risk of ARDS: evidence from the LIPS-A trial publication-title: Intensive Care Med doi: 10.1007/s00134-023-07244-z contributor: fullname: Fosset – volume: 48 start-page: 124 year: 2007 ident: R12 article-title: HLH-2004: diagnostic and therapeutic guidelines for Hemophagocytic Lymphohistiocytosis publication-title: Pediatr Blood Cancer doi: 10.1002/pbc.21039 contributor: fullname: Aricó – volume: 76 start-page: 1176 year: 2021 ident: R1 article-title: Attributable mortality of acute respiratory distress syndrome: a systematic review, meta-analysis and survival analysis using targeted minimum loss-based estimation publication-title: Thorax doi: 10.1136/thoraxjnl-2020-215950 contributor: fullname: Oromendia – volume: 10 year: 2020 ident: R10 article-title: Pro-inflammatory properties of H-Ferritin on human Macrophages, ex vivo and in vitro observations publication-title: Sci Rep doi: 10.1038/s41598-020-69031-w contributor: fullname: Berardicurti – volume: 2 start-page: e754 year: 2020 ident: R14 article-title: Clinical criteria for COVID-19-associated Hyperinflammatory syndrome: a cohort study publication-title: Lancet Rheumatol doi: 10.1016/S2665-9913(20)30343-X contributor: fullname: Jensen – volume: 3 year: 2022 ident: R13 article-title: Toward personalized Immunotherapy in sepsis: the PROVIDE randomized clinical trial publication-title: Cell Rep Med doi: 10.1016/j.xcrm.2022.100817 contributor: fullname: Antonakos – volume: 79 start-page: 219 year: 2024 ident: R7 article-title: Elevated Ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome publication-title: Thorax doi: 10.1136/thorax-2023-220292 contributor: fullname: Wick – volume: 77 start-page: 13 year: 2022 ident: R6 article-title: Latent class analysis-derived Subphenotypes are Generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study publication-title: Thorax doi: 10.1136/thoraxjnl-2021-217158 contributor: fullname: Chen – volume: 29 start-page: 2793 year: 2023 ident: R4 article-title: Robust airway Microbiome signatures in acute respiratory failure and hospital-acquired pneumonia publication-title: Nat Med doi: 10.1038/s41591-023-02617-9 contributor: fullname: Radder – volume: 371 start-page: 1695 year: 2014 ident: R8 article-title: Simvastatin in the acute respiratory distress syndrome publication-title: N Engl J Med doi: 10.1056/NEJMoa1403285 contributor: fullname: O’Kane – volume: 11 start-page: 98 year: 2018 ident: R19 article-title: It’s time to reverse our thinking. The reverse translation research paradigm publication-title: Clin Transl Sci doi: 10.1111/cts.12538 contributor: fullname: Shakhnovich – volume: 24 start-page: 217 year: 2023 ident: 2024032819550881000_79.3.200.20 article-title: Reverse translation: the key to increasing the clinical success of Immunotherapy publication-title: Genes Immun doi: 10.1038/s41435-023-00217-8 contributor: fullname: Vanmeerbeek – volume: 13 year: 2022 ident: 2024032819550881000_79.3.200.15 article-title: Interleukin-18 cytokine in immunity, inflammation, and Autoimmunity: biological role in induction, regulation, and treatment publication-title: Front Immunol doi: 10.3389/fimmu.2022.919973 contributor: fullname: Ihim – ident: 2024032819550881000_79.3.200.19 doi: 10.1111/cts.12538 – ident: 2024032819550881000_79.3.200.1 doi: 10.1136/thoraxjnl-2020-215950 – volume: 400 start-page: 1157 year: 2022 ident: 2024032819550881000_79.3.200.3 article-title: Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management publication-title: Lancet doi: 10.1016/S0140-6736(22)01439-8 contributor: fullname: Gorman – ident: 2024032819550881000_79.3.200.9 doi: 10.1056/NEJMoa1901686 – volume: 10 year: 2020 ident: 2024032819550881000_79.3.200.10 article-title: Pro-inflammatory properties of H-Ferritin on human Macrophages, ex vivo and in vitro observations publication-title: Sci Rep doi: 10.1038/s41598-020-69031-w contributor: fullname: Ruscitti – volume: 29 start-page: 2793 year: 2023 ident: 2024032819550881000_79.3.200.4 article-title: Robust airway Microbiome signatures in acute respiratory failure and hospital-acquired pneumonia publication-title: Nat Med doi: 10.1038/s41591-023-02617-9 contributor: fullname: Montassier – ident: 2024032819550881000_79.3.200.12 doi: 10.1002/pbc.21039 – ident: 2024032819550881000_79.3.200.11 doi: 10.1164/rccm.201201-0003OC – volume: 26 year: 2022 ident: 2024032819550881000_79.3.200.16 article-title: Sepsis Subphenotyping based on organ dysfunction trajectory publication-title: Crit Care doi: 10.1186/s13054-022-04071-4 contributor: fullname: Xu – volume: 74 start-page: 457 year: 2023 ident: 2024032819550881000_79.3.200.18 article-title: Biological Phenotyping in sepsis and acute respiratory distress syndrome publication-title: Annu Rev Med doi: 10.1146/annurev-med-043021-014005 contributor: fullname: Sinha – ident: 2024032819550881000_79.3.200.6 doi: 10.1136/thoraxjnl-2021-217158 – volume: 49 start-page: 1499 year: 2023 ident: 2024032819550881000_79.3.200.5 article-title: Inflammatory Subphenotypes in patients at risk of ARDS: evidence from the LIPS-A trial publication-title: Intensive Care Med doi: 10.1007/s00134-023-07244-z contributor: fullname: Redaelli – ident: 2024032819550881000_79.3.200.7 doi: 10.1136/thorax-2023-220455 – ident: 2024032819550881000_79.3.200.2 doi: 10.1136/thorax-2023-220262 – ident: 2024032819550881000_79.3.200.8 doi: 10.1056/NEJMoa1403285 – volume: 3 year: 2022 ident: 2024032819550881000_79.3.200.13 article-title: Toward personalized Immunotherapy in sepsis: the PROVIDE randomized clinical trial publication-title: Cell Rep Med doi: 10.1016/j.xcrm.2022.100817 contributor: fullname: Leventogiannis – volume: 2 start-page: e754 year: 2020 ident: 2024032819550881000_79.3.200.14 article-title: Clinical criteria for COVID-19-associated Hyperinflammatory syndrome: a cohort study publication-title: Lancet Rheumatol doi: 10.1016/S2665-9913(20)30343-X contributor: fullname: Webb – ident: 2024032819550881000_79.3.200.17 doi: 10.1136/thoraxjnl-2017-211090 |
SSID | ssj0008117 |
Score | 2.473237 |
Snippet | [...]measurement of those biomarkers can only be undertaken in the research laboratory setting. [...]it would be desirable if, instead of multiple biomarkers,... |
SourceID | proquest crossref pubmed bmj |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 200 |
SubjectTerms | Anesthesia ARDS Biomarkers Cell death Clinical medicine COVID-19 Critical Care Editorial Ferritins Humans Hypoxemia Latent class analysis Mortality Patients Phenotype Respiratory Distress Syndrome Sepsis Survival analysis Thorax |
Title | Identifying a hyperinflammatory subphenotype of ARDS associated with worse outcomes: may ferritin help? |
URI | http://dx.doi.org/10.1136/thorax-2023-221131 https://www.ncbi.nlm.nih.gov/pubmed/38286617 https://www.proquest.com/docview/2919439732/abstract/ https://www.proquest.com/docview/2926432042/abstract/ https://search.proquest.com/docview/2920187939 |
Volume | 79 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1baxQxFD50WxBfindXa4kg-CBhO0nmEl9K1dZFaJFqYd-Gk5urdGfW7izaf2_OXLb40D4OCZlwTnJy7h_AG4eFM9Hw4WliLFcmCdygU_wgCJkL4YJtG5ienmXTC_Vlls62YDrUwlBa5SATW0Htaks-8onQ0dyW1Ftmgoa8ALaZHC5_c8KPojhrD6Yxgh2RKArY7nw4Pvt6vpHKVFA5ZNBl8VYNBTQymzTzSO2_nIDEuYgGEQHOjczi1_9P1S36Z_sOnTyA3V6BZEcdxx_Clq8ewb3TPkT-GH50pbdt-RJDNr-mVsZViIxftAF1tlobyuuqyfnK6sCOzj99Y9hzyTtGnln2p75axdF1E4njV-_ZAq9ZoCaOzc-Kzf3l8vAJXJwcf_845T2aAjdSy4YnPsdc2qBDYnyCJs-D0oVzFgndW-deYZHFt0nbtECfCDywAq11mSK1C1P5FLaruvLPgWGSpca5aMhapxALdLKwGKzRKnUO_RjeRvKV_W1Yla2hIbOyI3RJhC47Qo_h3UDictm117hz9t7AhZvFbw7GLcNR5ZMiyqYxvN4MxztEgRGsfL1u5xA2oZZ6DM865m52I6nOPqp5L-7-90u4HzdKCT1c6D3Ybq7W_lVUVxqzD6N8lu_35zF-fZ4l_wC0auwQ |
link.rule.ids | 315,786,790,12083,21416,27957,27958,31754,31755,33779,33780,43345,43840,74102,74659 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELboVgIuiDcLBYyExAFZbWznYS5VgVYLdFeotFJv0fjFtmKTpckK-u_xJM5WHNqzrcSa8Yzn_RHy1kJhdXB8WJpow6ROPNNgJdvxXOScW2-6AabTWTY5kV9P09MYcGtiWeWgEztFbWuDMfJtroK7LXC2zO7yN0PUKMyuRgiNDbIpRXBVRmTz4_7s-9FaF2Mb5VA3lwVZGtpmRLbdzgON_zKED2c8uEEIM7ehF-f_P1DXWJ3d63Nwn9yLZiPd6_n8gNxy1UNyexoT44_Iz77htmtaokDnlzjAuPKB3YsujU6blcZqrhpDrrT2dO_o8w8KkTfOUozH0j_1RRNWV20giWs-0AVcUo-jG9uzis7dr-XuY3JysH_8acIihgLTQomWJS6HXBivfKJdAjrPvVSFtQYQ01vlTkKRhRdJmbQAl3DYMRyMsZlEYwtS8YSMqrpyzwiFJEu1tcF9NVYCFGBFYcAbrWRqLbgxeRfIV0YZaMrOvRBZ2RO6REKXPaHH5P1A4nLZD9W4cffWwIWrj19dh2uWg6EneNBIY_JmvRwkB9MhULl61e1BREIl1Jg87Zm7Po3A7vpg3D2_-d-vyZ3J8fSwPPwy-_aC3A2HxpIextUWGbUXK_cyGCytfhVv5T-ALelr |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ZbxMxELZokCpeEFdpaAEjIfGArGTtvcxLVVGicrRC0Ep5W40vAiK7aXcj6L9nZo9UPLTPtnatb2zPjOf4GHvtIHcGHR-RRMaK2ERBGHCxmAapMildsG0D05PT9Pg8_jRP5n3-U92nVQ53YntRu8rSG_lEanS3FfWWmYQ-LeLr0exgdSGIQYoirT2dxha7i1pySmwG2XzjfE2poHLIoEvxVA0FNCqdNAtE-68gInEh0SEiwrkts_z1v6q6wf5s9dDsAbvfG5D8sJP4Q3bHl4_Y9kkfIn_MfnSlt235Ege-uKJWxmVAwS_bgDqv14byuip6fOVV4Iffjr5z6KXkHaeXWf6nuqxxdN0gOL5-x5dwxQM1cWx-lnzhf68OnrDz2Yez98eiZ1MQRmnViMhnkCkbdIiMj8BkWYh17pwFYvfWmY8hT1E3aZvk4CMJUyvBWpfGZHZBonbYqKxKv8s4RGlinENH1roYIAencgvBGh0nzoEfszcIX9GfhrpoHQ2VFh3QBQFddECP2dsB4mLVtde4dfb-IIXrj19vjBuG0eRTEu-mMXu1GcYzRIERKH21bucQN6FWesyedsLdrEZRnT2aec9u__dLto3bsfjy8fTzHruHa6bcHiH1Phs1l2v_HC2Xxrxot-Q_VovsMQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identifying+a+hyperinflammatory+subphenotype+of+ARDS+associated+with+worse+outcomes%3A+may+ferritin+help%3F&rft.jtitle=Thorax&rft.au=Torres%2C+Lisa+K&rft.au=Siempos%2C+Ilias+I&rft.date=2024-01-29&rft.pub=BMJ+Publishing+Group+LTD&rft.issn=0040-6376&rft.eissn=1468-3296&rft.spage=thorax-2023-221131&rft_id=info:doi/10.1136%2Fthorax-2023-221131&rft.externalDBID=HAS_PDF_LINK |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0040-6376&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0040-6376&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0040-6376&client=summon |