Increased expression of forkhead box protein 3 gene of regulatory T cells in patients with active tuberculosis

• Published in: Inflammation & allergy drug targets Vol. 13; no. 5; p. 330
• Main Authors: Beiranvand, Elham, Abediankenari, Saeid, Rezaei, Mohammad Sadegh, Khani, Soghra, Sardari, Soroush, Beiranvand, Behnoush
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2014
• Subjects: Case-Control Studies; Cells, Cultured; Female; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gene Expression Regulation, Bacterial; Humans; Immunosuppression; Iran; Male; Mycobacterium tuberculosis - immunology; Sex Factors; T-Lymphocytes, Regulatory - immunology; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - immunology; Up-Regulation; Iran

Cell mediated immunity is the most important response against Mycobacterium tuberculosis (MTB). Regulatory T cells (Treg) play a vital role in suppressing the effector T cell response in tuberculosis (TB) patients. Forkhead box protein 3 (Foxp3) is an important regulator of Treg cells development an...