Blood RNA-sequencing across the continuum of ANA-positive autoimmunity reveals insights into initiating immunopathology

• Published in: Annals of the rheumatic diseases Vol. 83; no. 10; pp. 1322 - 1334
• Main Authors: Carter, Lucy Marie, Md Yusof, Md Yuzaiful, Wigston, Zoe, Plant, Darren, Wenlock, Stephanie, Alase, Adewonuola, Psarras, Antonios, Vital, Edward M
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and European League Against Rheumatism 01.10.2024; Elsevier Limited
• Subjects: Adult; Antibodies, Antinuclear - blood; Antibodies, Antinuclear - immunology; Antigens; Antinuclear antibodies; Autoantibodies; Autoimmune diseases; Autoimmunity; B-Lymphocytes - immunology; Case-Control Studies; CD4 antigen; Cytokines; Dendritic cells; Disease Progression; Electron transport chain; Female; Gene expression; Genomics; Humans; Immune response; Immunology; Interferon; Interferon Type I - genetics; Interferon Type I - immunology; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Lupus; Lupus Erythematosus, Systemic; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Lymphocytes B; Lymphocytes T; Lymphopenia; Male; Metabolic rate; Middle Aged; Oxidative phosphorylation; Peripheral blood mononuclear cells; Phosphorylation; Proteins; Risk Factors; Sequence Analysis, RNA; Systemic lupus erythematosus; Transcriptome; Transcriptomics; United Kingdom > UK; Autoimmunity; Autoantibodies; Lupus Erythematosus, Systemic; Risk Factors

ObjectiveMechanisms underpinning clinical evolution to systemic lupus erythematosus (SLE) from preceding antinuclear antibodies (ANA) positivity are poorly understood. This study aimed to understand blood immune cell transcriptional signatures associated with subclinical ANA positivity, and progress...