Blood RNA-sequencing across the continuum of ANA-positive autoimmunity reveals insights into initiating immunopathology - Carter, Lucy Marie; Md Yusof, Md Yuzaiful; Wigston, Zoe; Plant, Darren; Wenlock, Stephanie; Alase, Adewonuola; Psarras, Antonios; Vital, Edward M (Annals of the rheumatic diseases, 2024)
Keywords: Adult; Antibodies, Antinuclear - blood; Antibodies, Antinuclear - immunology; Antigens; Antinuclear antibodies; Autoantibodies; Autoimmune diseases; Autoimmunity; B-Lymphocytes - immunology; Case-Control Studies; CD4 antigen; Cytokines; Dendritic cells; Disease Progression; Electron transport chain; Female; Gene expression; Genomics; Humans; Immune response; Immunology; Interferon; Interferon Type I - genetics; Interferon Type I - immunology; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Lupus; Lupus Erythematosus, Systemic; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Lymphocytes B; Lymphocytes T; Lymphopenia; Male; Metabolic rate; Middle Aged; Oxidative phosphorylation; Peripheral blood mononuclear cells; Phosphorylation; Proteins; Risk Factors; Sequence Analysis, RNA; Systemic lupus erythematosus; Transcriptome; Transcriptomics; United Kingdom--UK; Autoimmunity; Autoantibodies; Lupus Erythematosus, Systemic; Risk Factors