Long-term exposure to diesel engine exhaust induces primary DNA damage: a population-based study

• Published in: Occupational and environmental medicine (London, England) Vol. 73; no. 2; pp. 83 - 90
• Main Authors: Duan, Huawei, Jia, Xiaowei, Zhai, Qingfeng, Ma, Lu, Wang, Shan, Huang, Chuanfeng, Wang, Haisheng, Niu, Yong, Li, Xue, Dai, Yufei, Yu, Shanfa, Gao, Weimin, Chen, Wen, Zheng, Yuxin
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group 01.02.2016; BMJ Publishing Group LTD
• Subjects: Adult; Air Pollutants, Occupational - adverse effects; Air Pollutants, Occupational - analysis; Air Pollution - adverse effects; Air Pollution - analysis; Bioassays; Biomarkers; Biomarkers - metabolism; Blood; Body mass index; Carbon; Carbon - adverse effects; Carbon - analysis; Carcinogens; Chemical hazards; Cigarette smoking; Comet Assay; Comets; Control groups; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; Deoxyribonucleic acid; Diesel engines; DNA; DNA Damage; DNA-Formamidopyrimidine Glycosylase - metabolism; Exhaust emissions; Factories; Health risks; Humans; Lung cancer; Lung neoplasms; Male; Manufacturing; Nitrogen dioxide; Nitrogen Dioxide - adverse effects; Nitrogen Dioxide - analysis; Occupational exposure; Occupational Exposure - adverse effects; Oxidative Stress; Particulate matter; Particulate Matter - adverse effects; Particulate Matter - analysis; Polycyclic aromatic hydrocarbons; Polycyclic Aromatic Hydrocarbons - adverse effects; Polycyclic Aromatic Hydrocarbons - analysis; Population studies; Population-based studies; Pyrenes - urine; Risk; Risk assessment; Sulfur; Sulfur dioxide; Sulfur Dioxide - adverse effects; Sulfur Dioxide - analysis; Urine; Vehicle Emissions - analysis; Work; Working hours; Workplace; Young Adult; China

ObjectivesDiesel engine exhaust (DEE) is a ubiquitous environmental pollutant and is carcinogenic to humans. To seek early and sensitive biomarkers for prediction of adverse health effects, we analysed the components of DEE particles, and examined the genetic and oxidative damages in DEE-exposed wor...