Reliability of Cyclotorsion measurements using Scanning Laser Ophthalmoscopy imaging in healthy subjects: the CySLO study

• Published in: British journal of ophthalmology Vol. 102; no. 4; pp. 535 - 538
• Main Authors: Lengwiler, Fabian, Rappoport, Daniel, Jaggi, Gregor P, Landau, Klara, Traber, Ghislaine L
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.04.2018
• Subjects: Adult; Eye movements; Eye Movements - physiology; Female; Humans; Male; Middle Aged; Myopia; Nerve Fibers; Neurological disorders; Ophthalmology; Ophthalmoscopy - methods; Ophthalmoscopy - standards; Optic nerve; Optics; Patients; Photography; Prospective Studies; Reproducibility of Results; Retina - diagnostic imaging; Tomography; Tomography, Optical Coherence - methods; Tomography, Optical Coherence - standards; Young Adult; Switzerland; Imaging
• DOI: 10.1136/bjophthalmol-2017-310396
• ISSN: 0007-1161

Background/aimsTo evaluate inter-rater and intra-rater reliability of objective cyclotorsion measurements obtained in healthy subjects using the Heidelberg Spectralis spectral domain—optical coherence tomography (SD-OCT) device.MethodsIn this prospective methodological study, 32 healthy subjects (14 men, 18 women; aged 21–64 years) were enrolled, 31 right eyes were examined and their foveo-papillary angles (FPAs) were measured. The retinal nerve fibre layer (RNFL) programme by Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany) was used to measure cyclotorsion based on the in-built algorithm for the measurement of the FPA on the scanning laser ophthalmoscopy (SLO) image. Repeated scans of the fixating and non-fixating right eye without and with eye tracker each were obtained by three different examiners.ResultsThe mean FPA measured overall by all three examiners was 6.6°±2.8°. The inter-rater reliability of the measured FPAs using the linear mixed effects model is estimated as rhointer=0.8803. The intra-rater reliability is estimated as rhointra=0.9589.ConclusionsRepeatability of objective cyclotorsion measurements within and between observers using the Heidelberg Spectralis OCT is very high. SD-OCT/SLO imaging is a reliable imaging technique to measure and study cyclotorsion.Clinical trial numberNCT02631369, Results.