Synthesis of New Thiosemicarbazones and Semicarbazones Containing the 1,2,3-1H-triazole-isatin Scaffold: Trypanocidal, Cytotoxicity, Electrochemical Assays, and Molecular Docking

• Published in: Medicinal chemistry (Shp-sariqah, United Arab Emirates) Vol. 15; no. 3; p. 240
• Main Authors: Silva, Bianca N M, Sales Junior, Policarpo A, Romanha, Alvaro J, Murta, Silvane M F, Lima, Camilo H S, Albuquerque, Magaly G, D'Elia, Eliane, Rodrigues, José G A, Ferreira, Vitor F, Silva, Fernando C, Pinto, Angelo C, Silva, Bárbara V
• Format: Journal Article
• Language: English
• Published: Netherlands 2019
• Subjects: trypanocidal; Chagas disease; thiosemicarbazone; semicarbazone; 1,2,3-triazole; isatin; Trypanosoma cruzi

Chagas disease, also known as American trypanosomiasis, is classified as one of the 17 most important neglected diseases by the World Health Organization. The only drugs with proven efficacy against Chagas disease are benznidazole and nifurtimox, however both show adverse effects, poor clinical effi...