Synergism between two amphenicol of antibiotics, florfenicol and thiamphenicol, against Staphylococcus aureus

• Published in: Veterinary record Vol. 178; no. 13; p. 319
• Main Authors: Wei, C.-F., Chang, S.-K., Shien, J.-H., Kuo, H.-C., Chen, W.-Y., Chou, C.-C.
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Limited 26.03.2016; Blackwell Publishing Ltd
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Antibiotic combination; Antibiotics; Antimicrobial agents; Bacteria; Cattle; Chickens; Drug resistance; Drug Synergism; Female; Florfenicol; Hypotheses; Laboratories; Mice; Molecular weight; Pathogens; Penicillin; Staphylococcal Infections - drug therapy; Staphylococcal Infections - veterinary; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - isolation & purification; Staphylococcus infections; Studies; Swine; Synergism; Thiamphenicol; Thiamphenicol - analogs & derivatives; Thiamphenicol - pharmacology; Veterinary medicine; Antibiotic combination; Thiamphenicol; Synergism; Florfenicol; Staphylococcus aureus

Synergistic effects between the same class of antibiotics are rarely reported. In the current study, two amphenicols, namely florfenicol and thiamphenicol, exhibited both in vitro and in vivo synergism against clinical isolates of Staphylococcus aureus from chickens, cattle and pigs. Checkerboard as...