Abnormal red blood cell morphological changes in thalassaemia associated with iron overload and oxidative stress

• Published in: Journal of clinical pathology Vol. 72; no. 8; pp. 520 - 524
• Main Authors: Chaichompoo, Pornthip, Qillah, Ariz, Sirankapracha, Pornpan, Kaewchuchuen, Jirada, Rimthong, Poramate, Paiboonsukwong, Kittiphong, Fucharoen, Suthat, Svasti, Saovaros, Worawichawong, Suchin
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2019
• Subjects: Anemia; Blood; Blood diseases; Disease; Hemoglobin; Iron; Light; Metabolism; Morphology; Oxidative stress; Reactive oxygen species; Scanning electron microscopy; Software; Thailand; iron overload; thalassemia; oxidative stress; red cell morphology

AimsIron overload is a major factor contributing to the overall pathology of thalassaemia, which is primarily mediated by ineffective erythropoiesis and shorter mature red blood cell (RBC) survival. Iron accumulation in RBCs generates reactive oxygen species (ROS) that cause cellular damage such as...