Lipoprotein(a): a risk factor for atherosclerosis and an emerging therapeutic target

• Published in: Heart (British Cardiac Society) Vol. 109; no. 1; pp. 18 - 25
• Main Authors: Di Fusco, Stefania Angela, Arca, Marcello, Scicchitano, Pietro, Alonzo, Alessandro, Perone, Francesco, Gulizia, Michele Massimo, Gabrielli, Domenico, Oliva, Fabrizio, Imperoli, Giuseppe, Colivicchi, Furio
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Cardiovascular Society 01.01.2023; BMJ Publishing Group LTD
• Subjects: Aortic Valve Stenosis - therapy; Apolipoproteins; Atherosclerosis; Atherosclerosis - drug therapy; Atherosclerosis - prevention & control; biomarkers; Cardiovascular disease; Cardiovascular Diseases - etiology; Cardiovascular Diseases - prevention & control; Cholesterol; Glycoproteins; Humans; hyperlipidemias; Hypolipidemic Agents - therapeutic use; Ischemia; Lipids; Lipoprotein(a); Lipoproteins; Low density lipoprotein receptors; pharmacology, clinical; Proteins; Review; Risk Factors; Statins; atherosclerosis; pharmacology, clinical; biomarkers; hyperlipidemias

Lipoprotein(a) (Lp(a)) is a complex circulating lipoprotein, and increasing evidence has demonstrated its role as a risk factor for atherosclerotic cardiovascular disease (ASCVD) and as a possible therapeutic target. Lp(a) atherogenic effects are attributed to several potential mechanisms in additio...