Histopathological abnormalities in the central arteries and veins of Fontan subjects

• Published in: Heart (British Cardiac Society) Vol. 104; no. 4; pp. 324 - 331
• Main Authors: Hays, Brandon S, Baker, Michael, Laib, Annie, Tan, Wei, Udholm, Sebastian, Goldstein, Bryan H, Sanders, Stephen P, Opotowsky, Alexander R, Veldtman, Gruschen R
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.02.2018
• Subjects: Age; Angioplasty; Bone marrow; Cardiac arrhythmia; Children & youth; Coronary vessels; Heart failure; Inflammation; Lymphocytes; Patients; Pulmonary arteries; Sepsis; Smooth muscle; Veins & arteries; United States > US; Fontan Physiology; Congenital Heart Disease; Vascular Biology

ObjectiveFontan circulations have obligatory venous hypertension, depressed cardiac output and abnormal arterial elastance. Ventriculovascular coupling is known to be abnormal, but the underlying mechanisms are poorly defined. We aim to describe the histopathological features of vascular remodelling...