(R)-9bMS Inhibited the Protein Synthesis and Autophagy of Triple Negative Breast Cancer Cells via Regulating miR-4660/mTOR Axis

• Published in: Protein and peptide letters Vol. 30; no. 4; p. 295
• Main Authors: Bai, Xiangdong, Han, Guohui, Li, Feng, Li, Weina, Bu, Peng, Zhang, Huanhu, Xie, Jun
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2023
• Subjects: Autophagy; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs - genetics; MicroRNAs - metabolism; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - metabolism; Protein-Tyrosine Kinases - pharmacology; TOR Serine-Threonine Kinases - metabolism; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; mTOR; breast cancer; protein synthesis; TNBC; miR-4660; (R)-9bMS

Unlike other subtypes of breast cancer, triple negative breast cancer (TNBC) exhibits aggressive and metastatic behaviors and a lack of effective targeted therapeutics. (R)-9bMS, a small-molecule inhibitor of the non-receptor tyrosine kinase 2 (TNK2), significantly inhibited TNBC cell growth; howeve...