Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc–xCT

• Published in: Gut Vol. 71; no. 12; pp. 2489 - 2501
• Main Authors: Tian, Shaobo, Chu, Yanan, Hu, Jia, Ding, Xueliang, Liu, Zhibo, Fu, Daan, Yuan, Ye, Deng, Yan, Wang, Guobin, Wang, Lin, Wang, Zheng
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.12.2022; BMJ Publishing Group LTD
• Subjects: Chemokines; Colon; Colorectal cancer; Colorectal carcinoma; Kinases; Leukocyte migration; Leukocytes (neutrophilic); liver metastases; Metastases; Metastasis; Microenvironments; Neutrophils; Peripheral blood; Protein kinase; Transforming growth factor-b1; Tumor microenvironment; Tumors; China; liver metastases; colorectal cancer

ObjectiveReciprocal cellular crosstalk within the tumour microenvironment (TME) actively participates in tumour progression. The anterior gradient-2 (AGR2) can be secreted to extracellular compartments and contribute to colorectal cancer (CRC) metastasis. We investigated the cellular source for secr...