Proton pump inhibitors and gastric cancer: association is not causation

• Published in: Gut Vol. 68; no. 8; pp. 1529 - 1530
• Main Authors: Moayyedi, Paul, Veldhuyzen van Zanten, Sander J O, Hookey, Lawrence, Armstrong, David, Jones, Nicola, Leontiadis, Grigorios I
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2019
• Subjects: Anti-Ulcer Agents; Gastric cancer; Gastroenterology; Helicobacter pylori; Humans; Proton Pump Inhibitors; Stomach Neoplasms; Canada; epidemiology; proton pump inhibition; gastric adenocarcinoma

The main problem for all database studies evaluating the risks of PPI is that none was specifically created to assess PPI-related events. [...]many confounders, such as socioeconomic status or comorbidities, are not recorded in sufficient detail to allow for adequate adjusting in a multivariate mode...