Ebola virus vaccine trials: the ethical mandate for a therapeutic safety net

[...]efforts to achieve equipoise by minimising the case fatality rate would impede efficacy assessment in treatment RCTs but not vaccine RCTs. [...]scientifically valid vaccine RCTs can and should minimise mortality risk by providing the best standard of care, including access to experimental thera...

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Published inBMJ (Online) Vol. 349; no. dec10 5; p. g7518
Main Authors Bellan, Steve E, Pulliam, Juliet R C, Dushoff, Jonathan, Meyers, Lauren Ancel
Format Journal Article
LanguageEnglish
Published England British Medical Journal Publishing Group 10.12.2014
BMJ Publishing Group LTD
BMJ Publishing Group Ltd
SeriesEbola
Subjects
Adolescent
Adult
Blood products
EBOLA
Ebola Vaccines
Ebola virus
Ethics
Fatalities
Hemorrhagic Fever, Ebola - mortality
Hemorrhagic Fever, Ebola - prevention & control
Humans
Letters
Mortality
Patient Safety
Randomized Controlled Trials as Topic - ethics
Randomized Controlled Trials as Topic - methods
Randomized Controlled Trials as Topic - mortality
Treatment Outcome
Vaccines
Young Adult
Guinea
Europe
Sierra Leone
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Summary:[...]efforts to achieve equipoise by minimising the case fatality rate would impede efficacy assessment in treatment RCTs but not vaccine RCTs. [...]scientifically valid vaccine RCTs can and should minimise mortality risk by providing the best standard of care, including access to experimental therapeutics, for any trial participant who develops the disease (figure ).
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0959-8138
1756-1833
1756-1833
DOI:10.1136/bmj.g7518