Suppressive Effect of Caffeic Acid and its Derivatives on the Generation of UVA-induced Reactive Oxygen Species in the Skin of Hairless Mice and Pharmacokinetic Analysis on Organ Distribution of Caffeic Acid in ddY Mice

• Published in: Photochemistry and photobiology Vol. 82; no. 6; pp. 1668 - 1676
• Main Authors: Yamada, Yumiko, Yasui, Hiroyuki, Sakurai, Hiromu
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2006
• Subjects: Acids; Animals; Caffeic Acids - pharmacokinetics; Caffeic Acids - pharmacology; Mice; Mice, Hairless; Organic chemicals; Oxygen; Pharmacokinetics; Plasma; Protective Agents - pharmacology; Purchasing; Reactive Oxygen Species - radiation effects; Research s; Skin; Skin - drug effects; Skin - radiation effects; Tissue Distribution; Ultraviolet Rays

Caffeic acid (CA) and its analogues such as rosmarinic acid are well known as antioxidative agents. Exposure to UVA is known to generate reactive oxygen species (ROS) such as singlet oxygen (1O2) and superoxide anion radical (·O2−) in the skin of animals, which in turn induces skin photodamage and p...