Passive immunotherapy against A beta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

• Published in: Journal of neuroinflammation Vol. 1; no. 1; p. 24
• Main Authors: Wilcock, Donna M, Rojiani, Amyn, Rosenthal, Arnon, Subbarao, Sangeetha, Freeman, Melissa J, Gordon, Marcia N, Morgan, Dave
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 08.12.2004; BioMed Central; BMC

Background Anti-A beta immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well past midlife, the current study examined adoptive transfer of anti-A beta anti...