Disruption of periaqueductal grey-default mode network functional connectivity predicts persistent post-traumatic headache in mild traumatic brain injury

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 90; no. 3; pp. 326 - 332
• Main Authors: Niu, Xuan, Bai, Lijun, Sun, Yingxiang, Wang, Shan, Cao, Jieli, Sun, Chuanzhu, Wang, Zhuonan, Xu, Hui, Gan, Shuoqiu, Fan, Geng, Huang, Wenmin, Gu, Chenghui, Yin, Bo, Bai, Guanghui, Xu, Xiaoling, Zhang, Ming
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.03.2019
• Subjects: Adult; Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - physiopathology; Brain Injuries, Traumatic - psychology; Case-Control Studies; Chronic illnesses; Education; Female; Head injuries; Headaches; Health care; Hospitals; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net - diagnostic imaging; Nerve Net - physiopathology; Neuropsychological Tests; Pain; Periaqueductal Gray - diagnostic imaging; Periaqueductal Gray - physiopathology; Post traumatic stress disorder; Post-Traumatic Headache - diagnostic imaging; Post-Traumatic Headache - etiology; Post-Traumatic Headache - physiopathology; Predictive Value of Tests; Time Factors; Trauma; Traumatic brain injury; Young Adult; United States > US; China

ObjectivePost-traumatic headache (PTH) is one of the most frequent and persistent physical symptoms following mild traumatic brain injury (mTBI) and develop in more than 50% of this population. This study aimed to investigate the periaqueductal grey (PAG)-seeded functional connectivity (FC) in patie...