THE EFFECT OF HYPOTHALAMIC STIMULATION AND PROGESTERONE ON OVULATION IN FEMALE RATS TREATED WITH THE OESTROGEN ANTAGONIST ICI 46,474

• Published in: Acta endocrinologica (Copenhagen) Vol. 72; no. 2; pp. 345 - 350
• Main Author: McDonald, P G
• Format: Journal Article
• Language: English
• Published: Denmark 01.02.1973
• Subjects: Animals; Castration; Depression, Chemical; Electric Stimulation; Estrogen Antagonists; Estrus; Ethylamines - pharmacology; Female; Hypothalamus; Organ Size; Ovulation - drug effects; Pentobarbital - pharmacology; Pregnancy; Progesterone - pharmacology; Rats; Stimulation, Chemical; Uterus - anatomy & histology; Uterus - drug effects

ABSTRACT A single dose (0.2 mg) of the antioestrogen ICI 46,474 at 15:00 h on the second day of dioestrus inhibited ovulation in the female rat. This inhibition could not be overcome by electrochemical stimulation of the basal hypothalamus on the afternoon of pro-oestrus. In contrast, progesterone (...