The new world of poly-(ADP)-ribose polymerase inhibitors (PARPi) used in the treatment of gynecological cancers

• Published in: International journal of gynecological cancer Vol. 30; no. 10; pp. 1608 - 1618
• Main Authors: Chelariu-Raicu, Anca, Zibetti Dal Molin, Graziela, Coleman, Robert L
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.10.2020
• Subjects: Biomarkers; Cervical cancer; Endometrial cancer; Gynecological cancer; Kinases; Mutation; Ovarian cancer; Uterine cancer; BRCA2 protein; BRCA1 protein; homologous recombination; ovarian cancer; uterine cancer

The clinical development of poly-(ADP)-ribose polymerase inhibitors (PARPi) began with the treatment of ovarian cancer patients harboring BRCA1/2 mutations and continues to be expanded to other gynecological cancers. Furthermore, The Cancer Genome Atlas (TCGA) analysis of endometrial and cervical ca...