Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners

• Published in: BMC chemical biology Vol. 9; no. 1; p. 5
• Main Authors: Fang, Jianwen, Koen, Yakov M, Hanzlik, Robert P
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.06.2009; BioMed Central

Protein covalent binding by reactive metabolites of drugs, chemicals and natural products can lead to acute cytotoxicity. Recent rapid progress in reactive metabolite target protein identification has shown that adduction is surprisingly selective and inspired the hope that analysis of target protei...