The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization

DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting checkpoint signals such as stalled replication forks or double-stranded DNA breaks, these pathways coordinate appropriate stress responses. Members of the PI-3 kinase...

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Published inBMC cell biology Vol. 7; no. 1; p. 32
Main Authors Baschal, Erin E, Chen, Kuan J, Elliott, Lee G, Herring, Matthew J, Verde, Shawn C, Wolkow, Tom D
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 24.08.2006
BioMed Central
BMC
Subjects
Actins - analysis
Benzimidazoles - pharmacology
Carbamates - pharmacology
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Polarity - drug effects
Chromosome Segregation - drug effects
Chromosome Segregation - genetics
Chromosome Segregation - physiology
Cytoplasm - metabolism
DNA Damage
DNA, Fungal - ultrastructure
Drug Resistance, Fungal
Epistasis, Genetic
Evolution, Molecular
Genes, cdc
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
Microtubules - drug effects
Microtubules - ultrastructure
Morphogenesis - genetics
Morphogenesis - physiology
Nucleic Acid Synthesis Inhibitors - pharmacology
Phleomycins - pharmacology
Phosphorylation - drug effects
Protein Processing, Post-Translational - drug effects
Schizosaccharomyces - drug effects
Schizosaccharomyces - genetics
Schizosaccharomyces - metabolism
Schizosaccharomyces - ultrastructure
Schizosaccharomyces pombe Proteins - genetics
Schizosaccharomyces pombe Proteins - metabolism
Spindle Apparatus - drug effects
Spindle Apparatus - ultrastructure
Thiabendazole - pharmacology
Transformation, Genetic
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Abstract DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting checkpoint signals such as stalled replication forks or double-stranded DNA breaks, these pathways coordinate appropriate stress responses. Members of the PI-3 kinase related kinase (PIKK) family are essential elements of DNA structure checkpoints. In fission yeast, the Rad3 PIKK and its regulatory subunit Rad26 coordinate the detection of checkpoint signals with pathway outputs. We found that untreated rad26Delta cells were defective for two microtubule-dependent processes: chromosome segregation and morphogenesis. Interestingly, cytoplasmic accumulation of Rad26-GFP occurred following treatment with microtubule destabilizing drugs, but not during treatment with the genotoxic agent Phleomycin. Cytoplasmic accumulation of Rad26-GFP depended on Rad24, a 14-3-3 protein also required for DNA structure checkpoints and morphogenesis. Results of over expression and epistasis experiments confirm that Rad26 and Rad24 define a response to microtubule destabilizing conditions. Two DNA structure checkpoint proteins with roles in morphogenesis define a response to microtubule destabilizing conditions.
AbstractList Abstract Background DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting checkpoint signals such as stalled replication forks or double-stranded DNA breaks, these pathways coordinate appropriate stress responses. Members of the PI-3 kinase related kinase (PIKK) family are essential elements of DNA structure checkpoints. In fission yeast, the Rad3 PIKK and its regulatory subunit Rad26 coordinate the detection of checkpoint signals with pathway outputs. Results We found that untreated rad26Δ cells were defective for two microtubule-dependent processes: chromosome segregation and morphogenesis. Interestingly, cytoplasmic accumulation of Rad26-GFP occurred following treatment with microtubule destabilizing drugs, but not during treatment with the genotoxic agent Phleomycin. Cytoplasmic accumulation of Rad26-GFP depended on Rad24, a 14-3-3 protein also required for DNA structure checkpoints and morphogenesis. Results of over expression and epistasis experiments confirm that Rad26 and Rad24 define a response to microtubule destabilizing conditions. Conclusion Two DNA structure checkpoint proteins with roles in morphogenesis define a response to microtubule destabilizing conditions.
Abstract Background DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting checkpoint signals such as stalled replication forks or double-stranded DNA breaks, these pathways coordinate appropriate stress responses. Members of the PI-3 kinase related kinase (PIKK) family are essential elements of DNA structure checkpoints. In fission yeast, the Rad3 PIKK and its regulatory subunit Rad26 coordinate the detection of checkpoint signals with pathway outputs. Results We found that untreated rad26Δ cells were defective for two microtubule-dependent processes: chromosome segregation and morphogenesis. Interestingly, cytoplasmic accumulation of Rad26-GFP occurred following treatment with microtubule destabilizing drugs, but not during treatment with the genotoxic agent Phleomycin. Cytoplasmic accumulation of Rad26-GFP depended on Rad24, a 14-3-3 protein also required for DNA structure checkpoints and morphogenesis. Results of over expression and epistasis experiments confirm that Rad26 and Rad24 define a response to microtubule destabilizing conditions. Conclusion Two DNA structure checkpoint proteins with roles in morphogenesis define a response to microtubule destabilizing conditions.
BACKGROUND: DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting checkpoint signals such as stalled replication forks or double-stranded DNA breaks, these pathways coordinate appropriate stress responses. Members of the PI-3 kinase related kinase (PIKK) family are essential elements of DNA structure checkpoints. In fission yeast, the Rad3 PIKK and its regulatory subunit Rad26 coordinate the detection of checkpoint signals with pathway outputs. RESULTS: We found that untreated rad26Δ cells were defective for two microtubule-dependent processes: chromosome segregation and morphogenesis. Interestingly, cytoplasmic accumulation of Rad26-GFP occurred following treatment with microtubule destabilizing drugs, but not during treatment with the genotoxic agent Phleomycin. Cytoplasmic accumulation of Rad26-GFP depended on Rad24, a 14-3-3 protein also required for DNA structure checkpoints and morphogenesis. Results of over expression and epistasis experiments confirm that Rad26 and Rad24 define a response to microtubule destabilizing conditions. CONCLUSION: Two DNA structure checkpoint proteins with roles in morphogenesis define a response to microtubule destabilizing conditions.
DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting checkpoint signals such as stalled replication forks or double-stranded DNA breaks, these pathways coordinate appropriate stress responses. Members of the PI-3 kinase related kinase (PIKK) family are essential elements of DNA structure checkpoints. In fission yeast, the Rad3 PIKK and its regulatory subunit Rad26 coordinate the detection of checkpoint signals with pathway outputs. We found that untreated rad26Delta cells were defective for two microtubule-dependent processes: chromosome segregation and morphogenesis. Interestingly, cytoplasmic accumulation of Rad26-GFP occurred following treatment with microtubule destabilizing drugs, but not during treatment with the genotoxic agent Phleomycin. Cytoplasmic accumulation of Rad26-GFP depended on Rad24, a 14-3-3 protein also required for DNA structure checkpoints and morphogenesis. Results of over expression and epistasis experiments confirm that Rad26 and Rad24 define a response to microtubule destabilizing conditions. Two DNA structure checkpoint proteins with roles in morphogenesis define a response to microtubule destabilizing conditions.
ArticleNumber 32
Author Herring, Matthew J
Baschal, Erin E
Verde, Shawn C
Chen, Kuan J
Wolkow, Tom D
Elliott, Lee G
AuthorAffiliation 1 University of Colorado at Colorado Springs, Department of Biology, 1420 Austin Bluffs Parkway, Colorado Springs, CO 80918, USA
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  year: 2006
  ident: 205_CR76
  publication-title: Science
  doi: 10.1126/science.1121513
  contributor:
    fullname: ZH Wu
SSID ssj0017810
Score 1.456582
Snippet DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting checkpoint signals such as...
Abstract Background DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting...
BACKGROUND: DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting checkpoint...
Abstract Background DNA structure checkpoints are conserved eukaryotic signal transduction pathways that help preserve genomic integrity. Upon detecting...
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StartPage 32
SubjectTerms Actins - analysis
Benzimidazoles - pharmacology
Carbamates - pharmacology
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Polarity - drug effects
Chromosome Segregation - drug effects
Chromosome Segregation - genetics
Chromosome Segregation - physiology
Cytoplasm - metabolism
DNA Damage
DNA, Fungal - ultrastructure
Drug Resistance, Fungal
Epistasis, Genetic
Evolution, Molecular
Genes, cdc
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
Microtubules - drug effects
Microtubules - ultrastructure
Morphogenesis - genetics
Morphogenesis - physiology
Nucleic Acid Synthesis Inhibitors - pharmacology
Phleomycins - pharmacology
Phosphorylation - drug effects
Protein Processing, Post-Translational - drug effects
Schizosaccharomyces - drug effects
Schizosaccharomyces - genetics
Schizosaccharomyces - metabolism
Schizosaccharomyces - ultrastructure
Schizosaccharomyces pombe Proteins - genetics
Schizosaccharomyces pombe Proteins - metabolism
Spindle Apparatus - drug effects
Spindle Apparatus - ultrastructure
Thiabendazole - pharmacology
Transformation, Genetic
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Title The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization
URI https://www.ncbi.nlm.nih.gov/pubmed/16930478
http://dx.doi.org/10.1186/1471-2121-7-32
https://pubmed.ncbi.nlm.nih.gov/PMC1592483
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