Rare and unusual spindle cell tumour

Chronic cervicitis Soft tissue sarcoma Spindle cell carcinoma A spindle cell variant of diffuse large B-cell lymphoma (DLBCL) Spindle cell melanoma The correct answer is after the discussion. There are a few case reports in the literature.2–4 Spindle cell lymphoma is associated with somatic immunogl...

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Bibliographic Details
Published inJournal of clinical pathology Vol. 73; no. 8; p. 526
Main Authors Nakamura, Harumi, Kitamura, Masanori, Murata, Hiroko, Kida, Shuhei, Ishikawa, Jun, Kamiura, Shoji, Nakatsuka, Shin-ichi
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group LTD 01.08.2020
Subjects
Biopsy
Cervix
Lymphoma
Melanoma
Morphology
Sarcoma
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Summary:Chronic cervicitis Soft tissue sarcoma Spindle cell carcinoma A spindle cell variant of diffuse large B-cell lymphoma (DLBCL) Spindle cell melanoma The correct answer is after the discussion. There are a few case reports in the literature.2–4 Spindle cell lymphoma is associated with somatic immunoglobulin and BCL6 gene mutations as well as BCL6 protein expression, and thus neoplastic spindle cells closely reflect B cells residing in the germinal centre.5 This indicates that spindle cell lymphoma is a good responder to chemotherapy and has a good prognosis. The differential diagnosis of spindle cell lymphoma of the uterine cervix includes chronic cervicitis, soft tissue sarcoma, spindle cell carcinoma, spindle cell melanoma and dendritic cell tumour.
Bibliography:ObjectType-Case Study-2
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ISSN:0021-9746
1472-4146
DOI:10.1136/jclinpath-2019-206144