Prostaglandin E2 functions as a luteotrophic factor in the dog

• Published in: Reproduction (Cambridge, England) Vol. 145; no. 3; pp. 213 - 226
• Main Authors: Kowalewski, Mariusz P, Fox, Barbara, Gram, Aykut, Boos, Alois, Reichler, Iris
• Format: Journal Article
• Language: English
• Published: England BioScientifica 01.03.2013
• Subjects: 3-Hydroxysteroid Dehydrogenases - metabolism; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme - metabolism; Dinoprostone - metabolism; Dogs; Estrous Cycle - genetics; Estrous Cycle - metabolism; Female; Gonadal Steroid Hormones - metabolism; Luteal Cells - metabolism; Organic Anion Transporters - genetics; Organic Anion Transporters - metabolism; Phosphoproteins - genetics; Phosphoproteins - metabolism; Pregnancy; Primary Cell Culture; Promoter Regions, Genetic; Receptors, Prostaglandin E, EP2 Subtype - metabolism; Receptors, Prostaglandin E, EP4 Subtype - metabolism; Signal Transduction; Time Factors; Transfection; Up-Regulation

The luteal phase in dogs is governed by many poorly understood regulatory mechanisms. Functioning of the corpus luteum (CL) is unaffected by hysterectomy. Recently, the role of prostaglandins in regulating canine CL function was addressed suggesting a luteotrophic effect of prostaglandin E2 (PGE2) d...