Predictive value of retinal atrophy for cognitive decline across disease duration in multiple sclerosis

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 95; no. 5; p. 419
• Main Authors: Alba-Arbalat, Salut, Solana, Elisabeth, Lopez-Soley, Elisabet, Camos-Carreras, Anna, Martinez-Heras, Eloy, Vivó, Francesc, Pulido-Valdeolivas, Irene, Andorra, Magi, Sepulveda, Maria, Cabrera, Jose María, Fonseca, Elianet, Calvi, Alberto, Alcubierre, Rafel, Dotti-Boada, Marina, Saiz, Albert, Martinez-Lapiscina, Elena H, Villoslada, Pablo, Blanco, Yolanda, Sanchez-Dalmau, Bernardo, Llufriu, Sara
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.05.2024
• Subjects: Atrophy - pathology; Cognition & reasoning; Cognitive ability; Cognitive Dysfunction - complications; Humans; Information processing; Longitudinal studies; Memory; Multiple sclerosis; Multiple Sclerosis - complications; Multiple Sclerosis - diagnostic imaging; Multiple Sclerosis - pathology; Neurodegeneration; Neuropsychology; Retina - pathology; Retinal Ganglion Cells - pathology; Standard scores; Survival analysis; Tomography; Tomography, Optical Coherence - methods; vision; cognition; multiple sclerosis; neuroophthalmology
• ISSN: 0022-3050; 1468-330X
• DOI: 10.1136/jnnp-2023-332332

We investigated the association between changes in retinal thickness and cognition in people with MS (PwMS), exploring the predictive value of optical coherence tomography (OCT) markers of neuroaxonal damage for global cognitive decline at different periods of disease. We quantified the peripapillary retinal nerve fibre (pRFNL) and ganglion cell-inner plexiform (GCIPL) layers thicknesses of 207 PwMS and performed neuropsychological evaluations. The cohort was divided based on disease duration (≤5 years or >5 years). We studied associations between changes in OCT and cognition over time, and assessed the risk of cognitive decline of a pRFNL≤88 µm or GCIPL≤77 µm and its predictive value. Changes in pRFNL and GCIPL thickness over 3.2 years were associated with evolution of cognitive scores, in the entire cohort and in patients with more than 5 years of disease (p<0.01). Changes in cognition were related to less use of disease-modifying drugs, but not OCT metrics in PwMS within 5 years of onset. A pRFNL≤88 µm was associated with earlier cognitive disability (3.7 vs 9.9 years) and higher risk of cognitive deterioration (HR=1.64, p=0.022). A GCIPL≤77 µm was not associated with a higher risk of cognitive decline, but a trend was observed at ≤91.5 µm in PwMS with longer disease (HR=1.81, p=0.061). The progressive retinal thinning is related to cognitive decline, indicating that cognitive dysfunction is a late manifestation of accumulated neuroaxonal damage. Quantifying the pRFNL aids in identifying individuals at risk of cognitive dysfunction.