Muscone Reduces OGD/R-Induced Hyperpermeability of the Brain Endothelial Barrier by Activating the PKA/RHOA/MLC Pathway

• Published in: Current neurovascular research
• Main Authors: Yang, Ziteng, Zuo, Yuanqi, Wang, Guangyun, Wang, Ning
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2025
• Subjects: actin cytoskeleton; apoptosis; endothelial barrier; PKA/RHOA/MLC pathway; Muscone; ischemic stroke

The endothelial barrier is composed of brain microvascular endothelial cells (BMECs) and tight junction (TJ) proteins. Musk is a valuable ingredient in Traditional Chinese Medicine (TCM). It is used in the treatment of stroke because of its ability to induce resuscitation. The core component of musk...