Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma

• Published in: Journal for immunotherapy of cancer Vol. 13; no. 8; p. e011091
• Main Authors: Chen, Weidong, Liao, Yan, Yao, Hao, Zou, Yutong, Fang, Ji, Zhang, Jiongfeng, Guo, Zehao, Tu, Jian, Chen, Junkai, Huo, Zijun, Wen, Lili, Xie, Xianbiao
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 22.08.2025; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Acidosis; Algorithms; Basic and Translational Cancer Immunology; Biomarkers; Bone Cancer; Cancer therapies; Cell cycle; Cell death; Datasets; Genes; Immune checkpoint inhibitors; Immune modulatory; Immunotherapy; Macrophage; Medical prognosis; Metabolism; Metabolites; Original Research; Survival analysis; Visualization

BackgroundOsteosarcoma is a highly aggressive cancer, and the efficacy of existing therapies has plateaued. Multiomics integration analysis can identify novel therapeutic targets for various cancers and therefore shows potential toward osteosarcoma treatment. This study aimed to leverage multiomics...