A Novel Tryptanthrin Derivative D6 Induces Apoptosis and DNA Damage in Non-small-cell Lung Cancer Cells Through Regulating the EGFR Pathway

• Published in: Anti-cancer agents in medicinal chemistry
• Main Authors: Long, Haitao, Zhang, Guanglong, Zhou, Yue, Qin, Liqing, Zhu, Danxue, Chen, Jiayi, Liu, Bo, Tan, Huayuan, Chen, Danping, Li, Zhurui, Li, Chengpeng, Wang, Zhenchao
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2024
• Subjects: apoptosis; proteomics; anti-cancer; tryptanthrin derivatives; EGFR; Non-small cell lung cancer

Non-small-cell lung cancer is a prevalent malignancy associated with significant morbidity and mortality rates. Tryptanthrin and its derivatives have exhibited potent antitumor activity. This study aims to investigate the inhibitory effect of a novel synthesized tryptanthrin derivative D6 on prolife...