COX-2 inhibitors are contraindicated for treatment of combined injury

• Published in: Radiation research Vol. 172; no. 6; p. 686
• Main Authors: Jiao, W, Kiang, J G, Cary, L, Elliott, T B, Pellmar, T C, Ledney, G D
• Format: Journal Article
• Language: English
• Published: United States 01.12.2009
• Subjects: Animals; Body Weight; Celecoxib; Contraindications; Cyclooxygenase Inhibitors - therapeutic use; Cytokines - blood; Dinoprostone - blood; Female; Mice; Pyrazoles - therapeutic use; Radiation Injuries - drug therapy; Sulfonamides - therapeutic use

Casualties of radiation dispersal devices, nuclear detonation or major ionizing radiation accidents, in addition to radiation exposure, may sustain physical and/or thermal trauma. Radiation exposure plus additional tissue trauma is known as combined injury. There are no definitive therapeutic agents...