Adenosine A2A Receptor Hyperexpression in Patients With Severe SIRS After Cardiopulmonary Bypass

• Published in: Journal of investigative medicine Vol. 56; no. 6; pp. 864 - 871
• Main Authors: Kerbaul, François, Bénard, Frédéric, Giorgi, Roch, Youlet, By, Carrega, Louis, Zouher, Ibrahim, Mercier, Laurence, Gérolami, Victoria, Bénas, Vincent, Blayac, Dorothée, Gariboldi, Vlad, Collart, Frédéric, Guieu, Régis
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.08.2008; Sage Publications Ltd
• Subjects: Adenosine; Adenosine - blood; Adult; Aged; Blood pressure; Cardiopulmonary Bypass - adverse effects; Case-Control Studies; Female; Gene Expression; Heart surgery; Hemodialysis; Hemodynamics; Humans; Inflammatory diseases; Laboratories; Male; Middle Aged; Neutrophils; Prospective Studies; Pulmonary hypertension; Receptors, Adenosine A2 - blood; Receptors, Adenosine A2 - genetics; RNA, Messenger - blood; RNA, Messenger - genetics; Sepsis; Systemic Inflammatory Response Syndrome - blood; Systemic Inflammatory Response Syndrome - etiology; Systemic Inflammatory Response Syndrome - genetics; Transplants & implants; France; adenosine; cardiopulmonary bypass; SIRS; A2A receptors; hemodynamics

ObjectiveAdenosine (ADO) is an endogenous nucleoside, which has been involved in blood pressure failure during severe systemic inflammatory response syndrome (severe SIRS) after cardiac surgery with cardiopulmonary bypass (CPB). Adenosine acts via its receptor subtypes, namely A1, A2A, A2B, or A3. B...