Determinants at the N- and C-termini of Gα12 required for activation of Rho-mediated signaling

• Published in: Journal of molecular signaling Vol. 8; no. 1; p. 3
• Main Authors: Ritchie, Benjamin J, Smolski, William C, Montgomery, Ellyn R, Fisher, Elizabeth S, Choi, Tina Y, Olson, Calla M, Foster, Lori A, Meigs, Thomas E
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.03.2013; BioMed Central

Heterotrimeric guanine nucleotide binding proteins of the G12/13 subfamily, which includes the α-subunits Gα12 and Gα13, stimulate the monomeric G protein RhoA through interaction with a distinct subset of Rho-specific guanine nucleotide exchange factors (RhoGEFs). The structural features that media...