Active Cushing syndrome patients have increased ectopic fat deposition and bone marrow fat content compared to cured patients and healthy subjects: a pilot 1H-MRS study

• Published in: European journal of endocrinology Vol. 179; no. 5; pp. 307 - 317
• Main Authors: Maurice, F, Dutour, A, Vincentelli, C, Abdesselam, I, Bernard, M, Dufour, H, Lefur, Y, Graillon, T, Kober, F, Cristofari, P, Jouve, E, Pini, L, Fernandez, R, Chagnaud, C, Brue, T, Castinetti, F, Gaborit, B
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.11.2018; Oxford Univ. Press
• Subjects: Absorptiometry, Photon; Adipose Tissue - diagnostic imaging; Adiposity - physiology; Adult; Bioengineering; Bone Density - physiology; Bone Marrow - diagnostic imaging; Clinical Study; Cross-Sectional Studies; Cushing Syndrome - diagnostic imaging; Female; Femur Neck - diagnostic imaging; Humans; Imaging; Life Sciences; Lumbar Vertebrae - diagnostic imaging; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Adipose tissue/metabolism; Cushing Syndrome/complications; Osteoporosis; Bone marrow fat; Glucocorticoids/adverse effects

Objective Glucocorticoid excess is one of the most important causes of bone disorders. Bone marrow fat (BMF) has been identified as a new mediator of bone metabolism. Cushing syndrome (CS) is a main regulator of adipose tissue distribution but its impact on BMF is unknown. The objective of the study...