Gonadotrophic activity of the guinea-pig placenta during pregnancy

• Published in: Journal of reproduction & fertility Vol. 65; no. 1; pp. 231 - 238
• Main Authors: Humphreys, E M, Hobson, B M, Wide, L
• Format: Journal Article
• Language: English
• Published: England 01.05.1982
• Subjects: Animals; Chorionic Gonadotropin - metabolism; Chromatography, Gel; Female; Guinea Pigs - metabolism; Hemagglutination Inhibition Tests; Placenta - metabolism; Pregnancy; Pregnancy, Animal; Radioimmunoassay

A gonadotrophic substance was extracted from placentae and subplacentae of guinea-pigs. Biological and immunological assays of these tissues obtained on Days 10-63 of pregnancy showed the highest mean concentration of the gonadotrophin on Day 18. Extracts chromatographed on Sephadex G200 had compone...