POPULATION PHARMACOKINETICS OF CEFPODOXIME IN BOTTLENOSE DOLPHINS ( TURSIOPS TRUNCATUS )

• Published in: Journal of zoo and wildlife medicine Vol. 55; no. 3; p. 611
• Main Authors: Linnehan, Barbara K, Lesman, Steven P, Boucher, Joseph F, Grover, G Scott, Brodie, Erin C, Meegan, Jennifer M, McClain, Abby M, Ross, Kyle P, Jensen, Eric D
• Format: Journal Article
• Language: English
• Published: United States 01.09.2024
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Area Under Curve; Bottle-Nosed Dolphin - blood; Cefpodoxime; Ceftizoxime - administration & dosage; Ceftizoxime - analogs & derivatives; Ceftizoxime - blood; Ceftizoxime - pharmacokinetics; Female; Half-Life; Male

Cefpodoxime proxetil is commonly used to treat cetacean patients with suspected or confirmed bacterial infections; however, pharmacokinetic data are needed to guide proper dosing in these species. Cefpodoxime proxetil is a time-dependent, semisynthetic, third-generation cephalosporin, appropriate fo...