TNF Alpha-Mediated Disruption of Spermatogenesis in Response to Sertoli Cell Injury in Rodents Is Partially Regulated by MMP21

• Published in: Biology of reproduction Vol. 80; no. 3; pp. 581 - 589
• Main Authors: Yao, Pei-Li, Lin, Yi-Chen, Richburg, John H
• Format: Journal Article
• Language: English
• Published: Society for the Study of Reproduction, Inc 01.03.2009
• Subjects: apoptosis; FAS; FASL; MEHP; MMP2; Sertoli cells; signal transduction; spermatogenesis; Testis; TIMP2; TNFA

Mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury in peripubertal rodents results in the stimulation of germ cell apoptosis through an interaction of FAS/FASL between these two cell types. During this peripubertal period, an early spike in the incidence of germ cell apoptosis occurs d...