A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsia

• Published in: Biology of reproduction Vol. 102; no. 3; pp. 560 - 570
• Main Authors: Wang, Hao, Zhao, Yangyu, Luo, Rongcan, Bian, Xiaotao, Wang, Yongqing, Shao, Xuan, Li, Yu-Xia, Liu, Ming, Wang, Yan-Ling
• Format: Journal Article
• Language: English
• Published: United States Society for the Study of Reproduction 13.03.2020; Oxford University Press
• Subjects: Binding sites; Biology; Blood pressure; CPEB2; HIF-1α; Hypertension; Hypoxia; MicroRNAs; miR-210; Placenta; Preeclampsia; Pregnancy complications; Reproductive health; Stem cells; trophoblast syncytialization; HIF-1α; preeclampsia; trophoblast syncytialization; CPEB2; miR-210

The pregnancy complication preeclampsia is directly associated with hypoxic stress and insufficient trophoblast cell differentiation. The hypoxia-inducible microRNA (miRNA), miR-210, has been identified as a significantly up-regulated miRNA in preeclamptic placenta, and evidence in other cell types...