Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD

• Published in: Thorax Vol. 74; no. 7; pp. 659 - 666
• Main Authors: Tregay, Nicola, Begg, Malcolm, Cahn, Anthony, Farahi, Neda, Povey, Kathryn, Madhavan, Sujith, Simmonds, Rosalind, Gillett, Daniel, Solanki, Chandra, Wong, Anna, Maison, Joanna, Lennon, Mark, Bradley, Glyn, Jarvis, Emily, de Groot, Marius, Wilson, Fred, Babar, Judith, Peters, A Michael, Hessel, Edith M, Chilvers, Edwin R
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Thoracic Society 01.07.2019; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original article
• Subjects: Biomarkers; Blood; Chronic obstructive pulmonary disease; copd pathology; Gene expression; Granulocytes; imaging/ct mri etc; Inflammation; innate immunity; Lung diseases; Lungs; neutrophil biology; Neutrophils; Respiratory Research; Systematic review; Thorax

RationaleThere is a need to develop imaging protocols which assess neutrophilic inflammation in the lung.AimTo quantify whole lung neutrophil accumulation in (1) healthy volunteers (HV) following inhaled lipopolysaccharide (LPS) or saline and (2) patients with COPD using radiolabelled autologous neu...