Acrosomal Swelling Is Triggered by cAMP Downstream of the Opening of Store-Operated Calcium Channels During Acrosomal Exocytosis in Human Sperm1

• Published in: Biology of reproduction Vol. 94; no. 3
• Main Authors: Sosa, Claudia M, Zanetti, M. Natalia, Pocognoni, Cristian A, Mayorga, Luis S
• Format: Journal Article
• Language: English
• Published: Society for the Study of Reproduction, Inc 01.03.2016
• Subjects: acrosomal swelling; acrosome reaction; calcium; cAMP; human sperm; regulated exocytosis; secretory granules

Acrosomal exocytosis in mammalian sperm is a regulated secretion with unusual characteristics. One of its most striking features is the postfusion loss of the outer acrosomal membrane and the overlying plasma membrane as hybrid vesicles. We have previously reported in human sperm that, by preventing...