Ras-mediated homeostatic control of front-back signaling dictates cell polarity

• Published in: bioRxiv
• Main Authors: Lin, Yiyan, Pal, Dhiman Sankar, Banerjee, Parijat, Banerjee, Tatsat, Qin, Guanghui, Deng, Yu, Borleis, Jane, Iglesias, Pablo A, Devreotes, Peter N
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 01.09.2023
• Edition: 1.1
• Subjects: Cell Biology; actin cytoskeleton; signaling; biochemical excitability; optogenetics; cancer metastasis

Studies in the model systems, amoebae and HL-60 neutrophils, have shown that local Ras activity directly regulates cell motility or polarity. Localized Ras activation on the membrane is spatiotemporally regulated by its activators, RasGEFs, and inhibitors, RasGAPs, which might be expected to create...