Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant

• Published in: bioRxiv
• Main Authors: Scheaffer, Suzanne M, Lee, Diana, Whitener, Bradley, Ying, Baoling, Wu, Kai, Jani, Hardik, Martin, Philippa, Amato, Nicholas J, Avena, Laura E, Berrueta, Daniela Montes, Schmidt, Stephen D, O'Dell, Sijy, Nasir, Arshan, Chuang, Gwo-Yu, Stewart-Jones, Guillaume, Koup, Richard A, Doria-Rose, Nicole A, Carfi, Andrea, Elbashir, Sayda M, Thackray, Larissa B, Edwards, Darin K, Diamond, Michael S
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 13.09.2022
• Edition: 1.1
• Subjects: Microbiology

The emergence of SARS-CoV-2 variants in the Omicron lineage with large numbers of substitutions in the spike protein that can evade antibody neutralization has resulted in diminished vaccine efficacy and persistent transmission. One strategy to broaden vaccine-induced immunity is to administer bival...