Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin-Releasing Hormone Neurons1

• Published in: Biology of reproduction Vol. 81; no. 4; pp. 690 - 699
• Main Authors: Adewale, Heather B, Jefferson, Wendy N, Newbold, Retha R, Patisaul, Heather B
• Format: Journal Article
• Language: English
• Published: Society for the Study of Reproduction, Inc 01.10.2009
• Subjects: AVPV; corpora lutea; development; disruption; endocrine disruptors; ERα; ESR1; estradiol; estradiol receptor; estrogen; estrogen receptor; GnRH; gonad; hypothalamus; lordosis; neuroendocrinology; ovary; PPT; puberty

Developmental exposure to endocrine-disrupting compounds is hypothesized to adversely affect female reproductive physiology by interfering with the organization of the hypothalamic-pituitary-gonadal axis. Here, we compared the effects of neonatal exposure to two environmentally relevant doses of the...