POS0440 INCREASED FREQUENCY OF ACTIVATED MAIT CELLS EXPRESSING THE GUT HOMING RECEPTOR CCR9 IN PATIENTS WITH RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS

• Published in: Annals of the rheumatic diseases Vol. 82; no. Suppl 1; pp. 475 - 476
• Main Authors: Toussirot, E., Laheurte, C., Gravelin, E., Vauchy, C., Puyraveau, M., Saas, P.
• Format: Journal Article
• Language: English
• Published: Kidlington BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2023; Elsevier B.V; Elsevier Limited
• Subjects: Age; Ankylosing spondylitis; Arthritis; CC chemokine receptors; CD3 antigen; CD4 antigen; CD49d antigen; CD69 antigen; CD8 antigen; Chemokine receptors; Chemokines; Dipeptidyl-peptidase IV; Flow cytometry; Gastrointestinal tract; Homing receptors; Inflammatory diseases; Innate immunity; Interleukin 17; Interleukin 22; Lymphocytes T; Mucosa; Nonsteroidal anti-inflammatory drugs; Peripheral blood; Rheumatic diseases; Scientific Abstracts; Spondyloarthritis; T cell receptors; γ-Interferon; Innate immunity; Spondyloarthritis; Gastrointestinal tract

BackgroundMAIT (mucosal associated invariant T) cells are involved in mucosa defense against bacteria. This cellular subset is characterized by a semi-invariant αβ TCR and the expression of CD161. In patients with axial spondyloarthritis (ax SpA), previous works reported a decreased frequency of cir...