AB0727 A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO EVALUATE THE EFFICACY OF METHOTREXATE AS REMISSION MAINTENANCE THERAPY AFTER REMISSION-INDUCTION THERAPY WITH TOCILIZUMAB AND GLUCOCORTICOIDS IN SUBJECTS WITH GIANT CELL ARTERITIS (METEORITICS TRIAL): STUDY PROTOCOL

• Published in: Annals of the rheumatic diseases Vol. 82; no. Suppl 1; p. 1569
• Main Authors: Kreis, L., Schmidt, W. A., Venhoff, N., Dejaco, C., Schäfer, V.
• Format: Journal Article
• Language: English
• Published: Kidlington BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2023; Elsevier B.V; Elsevier Limited
• Subjects: Arteries; Arteritis; Clinical trials; Disease-modifying drugs (DMARDs); Double-blind studies; Glomerular filtration rate; Glucocorticoids; Immunomodulation; Induction therapy; Intolerance; Magnetic resonance imaging; Methotrexate; Monoclonal antibodies; Placebos; Remission; Scientific Abstracts; Systemic vasculitis; Vasculitis; Vein & artery diseases; Disease-modifying drugs (DMARDs); Clinical trials; Vasculitis

BackgroundGiant cell arteritis (GCA) is the most common systemic vasculitis found in adults over 50 years of age and affects medium and large vessels. The standard treatment is glucocorticoids (GC). Because of the negative side effects of GC and the high prevalence of relapses GC should be combined...