SAT0066 The long noncoding rna (LNCRNA) hottip is a master regulator of cell cycle in hand synovial fibroblasts in arthritis

• Published in: Annals of the rheumatic diseases Vol. 77; no. Suppl 2; pp. 896 - 897
• Main Authors: Frank Bertoncelj, M., Masterson, T., Karouzakis, E., Kolling, C., Filer, A., Buckley, C.D., Gay, S., Distler, O., Ospelt, C.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Limited 01.06.2018
• Subjects: Annexin V; Apoptosis; Arthritis; Cell cycle; Cycle protein; Data processing; Deoxyribonucleic acid; DNA; DNA methylation; Enhancers; Epigenetics; Feet; Fibroblasts; Genomes; Hyperplasia; Inflammation; Joint diseases; Knee; Osteoarthritis; Protein interaction; Proteins; Rheumatoid arthritis; Ribonucleic acid; RNA; Shoulder; Stromal cells; Synovium

BackgroundRheumatoid arthritis (RA) and other types of inflammatory arthritis follow a characteristic anatomical pattern of joint involvement. We have recently shown that local synovial stromal cells, specifically synovial fibroblasts, exhibit joint-specific transcriptomes and functions. In particul...